Rx
🏭 HBI
❄️ Cold Chain
⭐ WHO Prequalified
💉 PVRV
🐾 Anti-Rabies
ABHAYRAB® · Human Biologicals Institute · Freeze-Dried Vaccine + WFI Diluent · Intramuscular Injection
Vero Cell Rabies Vaccine · ≥2.5 IU per Dose · Freeze-Dried · HBI India
👥 Who Should Get ABHAYRAB?
Rabies is almost always fatal once symptoms begin, so prompt vaccination after any significant exposure is essential. ABHAYRAB is recommended for:
- Anyone with a Category II or III bite, scratch, or exposure from a dog, cat, monkey, bat or other mammal — post-exposure prophylaxis, regardless of age, pregnancy or immune status.
- High-risk occupational groups for pre-exposure prophylaxis: veterinarians, animal handlers, wildlife and forest department staff, and laboratory workers handling rabies virus.
- Travelers to rabies-endemic regions, including remote parts of India, with limited access to timely medical care.
- Children, who account for a large share of dog-bite cases in India and are a priority group for pre-exposure vaccination in high-incidence areas.
- Anyone previously fully vaccinated who is re-exposed — only booster doses are needed rather than a full course again.
🔬 ABHAYRAB Composition – Per Reconstituted 0.5 mL Dose
Each freeze-dried vial, reconstituted with the supplied Water for Injection diluent, contains:
| Component | Quantity | Notes |
|---|---|---|
| ACTIVE INGREDIENT | ||
| Inactivated Rabies Virus (Pitman-Moore / L strain), propagated on Vero cells Inactivated with beta-propiolactone |
≥2.5 IU | Potency meets WHO/IP requirement for human rabies vaccines (minimum 2.5 IU per dose) |
| PRESENTATION & DILUENT | ||
| Stabilizers and excipients | q.s. | Maintain vaccine stability during freeze-drying and cold storage; exact excipients per manufacturer's package insert |
| Water for Injection (diluent, supplied separately) | 0.5 mL per dose | Used to reconstitute the freeze-dried pellet immediately before administration |
| WHAT IT DOES NOT CONTAIN | ||
| Live rabies virus | None | The vaccine is fully inactivated and cannot cause rabies |
📅 ABHAYRAB Vaccination Schedule
| Regimen / Group | Number of Doses | Timing | Notes |
|---|---|---|---|
| POST-EXPOSURE PROPHYLAXIS (PEP) — AFTER A BITE OR SCRATCH | |||
| Essen Regimen (Intramuscular) | 4–5 Doses | Day 0, 3, 7, 14 (Day 28 optional / for immunocompromised) | WHO / India NRCP standard regimen; start immediately after exposure |
| Zagreb / 2-1-1 Regimen (Intramuscular) | 4 Doses | Day 0 (2 doses, one in each deltoid), Day 7 (1 dose), Day 21 (1 dose) | WHO-approved alternative; completed in 3 visits instead of 4–5 |
| PRE-EXPOSURE PROPHYLAXIS (PrEP) — HIGH-RISK GROUPS, BEFORE EXPOSURE | |||
| Standard PrEP Schedule | 3 Doses | Day 0, 7, 21 or 28 | Recommended for vets, animal handlers, high-risk travelers, children in endemic areas |
| Booster (Re-Exposed, Previously Vaccinated) | 2 Doses | Day 0 and Day 3 | Full course not required if a complete prior course is documented |
⚠️ Rabies Immunoglobulin (RIG) is required alongside the vaccine for Category III exposures (or Category II in immunocompromised individuals) and is administered separately around the wound, as advised by the treating doctor.
⚙️ How Does ABHAYRAB Work?
1
Inactivated Antigen Delivered Intramuscularly
0.5 mL of reconstituted ABHAYRAB is injected into the deltoid (or anterolateral thigh in infants), delivering inactivated rabies virus glycoprotein antigens grown on Vero cells. No live virus is present, so the vaccine itself cannot cause rabies.
2
Immune Recognition and Antibody Production
Antigen-presenting cells process the rabies glycoprotein and present it to T-helper cells, triggering B-cells to begin producing rabies virus neutralizing antibodies (RVNA) over the following 7–14 days.
3
Passive Protection Bridges the Gap
Because active immunity takes days to build up, Category III exposures also receive Rabies Immunoglobulin around the wound for immediate passive protection until vaccine-induced immunity takes over.
4
Completed Course Gives Long-Lasting Protection
Finishing all doses on schedule (Essen or Zagreb regimen) generates protective antibody titers that neutralize any rabies virus at the exposure site before it can reach the central nervous system, preventing the disease.
⚠️ ABHAYRAB Side Effects
ABHAYRAB has a well-established safety record. Most recipients experience only mild, short-lived reactions.
🟡 Common (Mild, 1–2 Days)
- 💉 Injection-site pain, swelling or redness
- 🔴 Itching or induration at injection site
- 🤕 Headache (mild)
- 🌡️ Low-grade fever
- 💪 Myalgia (muscle ache)
- 😴 Fatigue or malaise
🔴 Rare — Seek Medical Attention Immediately
- 😮💨 Difficulty breathing or facial/throat swelling (anaphylaxis)
- 🌡️ High fever (above 39.5°C / 103°F)
- 🟣 Widespread rash or hives beyond the injection site
- 🦵 Unusual weakness, tingling or numbness
- 😵 Fainting or severe dizziness shortly after injection
⚖️ ABHAYRAB vs Other Rabies Vaccines Available in India
| Feature | ABHAYRAB (HBI) | Rabivax-S (Serum Institute) | Verorab (Sanofi, imported) |
|---|---|---|---|
| Cell Substrate | ✓ Vero Cell (PVRV) | Purified Chick Embryo Cell (PCECV) | ✓ Vero Cell (PVRV) |
| WHO Prequalified | ✓ Yes | ✓ Yes | ✓ Yes |
| Country of Manufacture | ✓ Made in India | ✓ Made in India | Imported (France) |
| Approved Routes | Intramuscular | Intramuscular / Intradermal | Intramuscular / Intradermal |
| Use Case | PEP & PrEP | PEP & PrEP | PEP & PrEP |
| Price Tier at VacciHub | ✓ Economical, India-manufactured | ✓ Economical, India-manufactured | Premium (imported product) |
🚫 Precautions and Contraindications
Important Note for Post-Exposure Prophylaxis (PEP):
- Rabies is almost always fatal once symptoms appear, so there are no absolute contraindications to post-exposure vaccination after a significant bite — it must be given regardless of pregnancy, breastfeeding, age or allergy history, with reactions managed symptomatically if they occur.
Use with Caution — Consult Doctor First (mainly for Pre-Exposure Prophylaxis):
- Moderate to severe acute febrile illness — defer routine PrEP dosing until recovery (not applicable to PEP, which should never be delayed)
- History of severe allergic reaction to a previous dose of this vaccine or any of its components
- Immunocompromised individuals (HIV, chemotherapy, chronic steroid use) — may require an additional dose and antibody titer testing after the primary course
Do NOT Delay Vaccination For:
- Mild cold, cough or low-grade fever
- Uncertainty about the biting animal's vaccination status — begin PEP immediately; it can be discontinued later only if the animal is proven healthy after the WHO-recommended 10-day observation period (dogs/cats only)
🏥 Why Book ABHAYRAB with VacciHub?
Certified Nursing Staff
Nurses trained and experienced in rabies post-exposure protocols for all ages. Correct IM injection technique and pre-vaccination assessment on every home visit.
End-to-End Cold Chain
ABHAYRAB transported in validated cold boxes at 2–8°C, never frozen. Temperature data logged, with cold chain compliance certificate available on request.
Genuine HBI ABHAYRAB
Sourced exclusively from authorised distributors of Human Biologicals Institute. Batch number and expiry date shared on WhatsApp receipt post-vaccination.
Rapid Response for Bite Cases
Same-day and emergency slots for post-exposure prophylaxis, since starting the vaccine promptly after a bite is critical to prevent disease.
Dose Reminder Service
Automatic WhatsApp reminders for your Day 3/7/14/21/28 follow-up doses so no dose in your schedule is ever missed.
📍 ABHAYRAB Home Vaccination – Cities We Serve
🏛️Delhi (All Areas)
🏙️Gurgaon
🌆Noida
🏘️Ghaziabad
🏗️Faridabad
🌇Greater Noida
Call +91 92050 04114 to confirm service availability for your specific pincode — same-day slots available in most areas, important for timely post-exposure prophylaxis.
❓ Frequently Asked Questions – ABHAYRAB
ABHAYRAB is a Purified Vero Cell Rabies Vaccine (PVRV) manufactured by Human Biologicals Institute (HBI). It is an inactivated, freeze-dried vaccine used for both post-exposure and pre-exposure prophylaxis against rabies.
Vaccination should begin as soon as possible after any Category II or III exposure — a bite, scratch, or lick on broken skin or mucous membrane — ideally on the same day. Do not wait to see if the animal shows symptoms of rabies.
Both are WHO-approved intramuscular post-exposure schedules. The Essen regimen uses single doses on Days 0, 3, 7, 14 (and sometimes 28). The Zagreb (2-1-1) regimen uses two doses on Day 0 followed by single doses on Days 7 and 21, completing the course in three visits instead of four to five.
RIG is recommended in addition to the vaccine for Category III exposures (or Category II in immunocompromised individuals) to provide immediate passive protection while active immunity develops. Your treating doctor will assess the exposure category and advise if RIG is required.
Yes. Post-exposure rabies vaccination should never be withheld from pregnant or breastfeeding women, as untreated rabies is fatal. ABHAYRAB has not been shown to pose a risk to the fetus or infant.
ABHAYRAB is priced at ₹900 per dose at VacciHub, with home vaccination available across Delhi NCR. A small pincode-based delivery or nursing visit fee may apply depending on your location.
If you complete the full post-exposure or pre-exposure course, no routine booster is needed unless you are re-exposed to a bite in future, or belong to a continuously high-risk occupational group requiring periodic titer monitoring.
Most people experience only mild, short-lived injection-site pain, redness or swelling, and occasionally mild fever or headache. Serious reactions such as anaphylaxis are rare.
Yes. VacciHub provides certified nurses for home-based ABHAYRAB vaccination across Delhi, Gurgaon, Noida, Ghaziabad and Faridabad, including urgent same-day visits for bite cases.