BIOVAC TCV · Dr. Reddy's Laboratories · 0.5 mL Single Dose · Intramuscular Injection
Typhoid Vi Conjugate Vaccine · Dr. Reddy's Laboratories
A systemic bacterial infection caused by Salmonella Typhi, spread through contaminated food and water. Causes prolonged high fever, headache, abdominal pain and can be serious if untreated.
India remains one of the countries with the highest typhoid burden globally, with children between 2-15 years being at particularly high risk, especially in dense urban areas.
Drug-resistant strains of typhoid are increasingly reported, making prevention through vaccination an important strategy alongside safe food and water practices.
Conjugate typhoid vaccines like BIOVAC TCV generate immune memory and can be used in younger children, unlike older polysaccharide-only vaccines limited to ages 2 and above.
BIOVAC TCV can be given from 6 months of age, allowing early protection during a high-risk window not covered by older typhoid vaccines.
Children are among the highest-risk groups for typhoid infection in India and benefit from the longer-lasting protection offered by conjugate vaccines.
Recommended before travel to South Asia, Southeast Asia, Africa or any region with poor sanitation and known typhoid risk.
Adults living in dense urban areas with variable water quality, food handlers and sanitation workers may benefit from vaccination.
Persons handling Salmonella Typhi samples in diagnostic or research laboratories are often advised to be vaccinated as an occupational precaution.
People with reduced immunity may still be considered for vaccination after consulting their doctor, as BIOVAC TCV does not contain a live organism.
As a Typhoid Vi Conjugate Vaccine, each 0.5 mL dose is formulated broadly along the following lines. Please refer to the manufacturer package insert supplied with your dose for exact quantities and excipients.
| Component | Role |
|---|---|
| Purified Vi Capsular Polysaccharide of Salmonella Typhi | Active antigen that induces protective antibodies |
| Carrier Protein (conjugated) | Enables a stronger, T-cell supported immune response and memory |
| Buffering salts / Sodium Chloride | Tonicity adjustment |
| Water for Injection | Vehicle, made up to 0.5 mL |
| Group | Dose | Timing | Notes |
|---|---|---|---|
| Infants (routine) | 1 Dose | 9–12 months | As per IAP extended schedule, often alongside MMR/MR |
| Children 2–15 years (catch-up) | 1 Dose | Any time | Single dose; repeat roughly every 3 years in high exposure settings |
| Adults | 1 Dose | Any time | Repeat roughly every 3 years if continued risk (travel, occupation) |
| Pre-travel | 1 Dose | ≥2 weeks before travel | Recommended for travel to typhoid-endemic regions |
The 0.5 mL dose delivers purified Vi capsular polysaccharide of S. Typhi conjugated to a carrier protein, given intramuscularly.
Conjugation recruits helper T-cells, converting the response from a weaker T-independent reaction (as with plain polysaccharide vaccines) into a stronger, memory-forming response.
The immune system produces IgG antibodies against the Vi antigen, with memory cells enabling a faster response on future exposure.
Protective immunity typically develops within about two weeks of vaccination and is generally longer-lasting than with older polysaccharide-only vaccines.
Typhoid conjugate vaccines generally have a well-established safety profile. As with any vaccine, side effects can occur:
Pain or tenderness at injection site · Mild redness or swelling · Low-grade fever · Irritability in infants · Mild fatigue
High fever above 39°C · Prolonged crying in infants · Extensive swelling at injection site · Signs of a severe allergic reaction
Do NOT take BIOVAC TCV if:
• You have a known severe allergy to any component of the vaccine or had a severe reaction to a previous dose.
• You currently have an acute moderate-to-severe febrile illness – vaccination should be deferred until recovery.
Use with caution / discuss with your doctor:
• Immunosuppressed individuals, where response may be reduced.
• Pregnancy – only if clearly needed, after medical advice.
• Bleeding disorders or those on blood thinners.
Trained nurses experienced in paediatric and adult vaccination with correct IM technique.
Validated cold boxes maintain 2-8°C from warehouse to your home.
Sourced through authorised channels with traceable batch numbers.
Skip queues and hospital exposure – the nurse comes to you.
Vaccination history and batch details shared after every visit.
Flexible scheduling including short-notice pre-travel bookings.
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