Rx
Abbott India
Mfg: Bharat Biotech
Cold Chain
Typhoid Vi Conjugate
Enteroshield - Abbott India - 0.5 mL Single Dose PFS - Intramuscular Use Only
Composition - Storage 2-8C - Mfd by Bharat Biotech - Marketed by Abbott India - Verified by VacciHub
What is Typhoid and Why Vaccinate?
Typhoid Fever
A life-threatening systemic infection caused by Salmonella typhi. Spreads via contaminated food and water. Causes sustained high fever, severe headache, abdominal pain and can progress to intestinal perforation or sepsis if untreated.
India's High Burden
India reports an estimated 4-6 million typhoid cases per year. Delhi NCR, Noida and Ghaziabad are high-risk zones due to population density and variable sanitation. Children aged 2-15 bear the highest burden.
Drug Resistance (XDR Typhoid)
Extensively Drug-Resistant (XDR) typhoid resistant to multiple antibiotics is spreading rapidly. Vaccination with TCV is now the most reliable and cost-effective prevention strategy against even drug-resistant strains.
Why TCV is the Gold Standard
Conjugate technology (Vi + Tetanus Toxoid) generates T-cell memory - protection from 6 months, longer duration, booster effect on re-exposure. WHO recommends TCV over plain polysaccharide vaccines globally.
Who Should Get Enteroshield 0.5?
Infants from 6 Months
Enteroshield can be given from 6 months of age - unlike older typhoid vaccines limited to 2 years+. IAP recommends first dose at 9-12 months for routine vaccination.
Children 1-15 Years
Highest-risk age group for typhoid in India. Single dose provides strong protection. Booster at 2 years if primary dose was given before 2nd birthday.
Pre-Travel Vaccination
Travelling to typhoid-endemic areas - South Asia, Southeast Asia, Sub-Saharan Africa. Book Enteroshield at home 2 or more weeks before departure with VacciHub.
Adults in High-Risk Areas
Adults in Delhi NCR with unreliable water supply, food handlers, sanitation workers and healthcare staff dealing with enteric fever cases.
Microbiology Lab Workers
Occupational exposure to Salmonella typhi. Typhoid vaccination is recommended in microbiology and reference laboratories per occupational health guidelines.
Immunocompromised Individuals
HIV-positive, transplant patients and those on immunosuppressive therapy face higher typhoid risk. Consult your doctor - TCV is generally recommended with appropriate caution.
Enteroshield Composition - Per 0.5 mL Dose
As per Abbott India / Bharat Biotech manufacturer label. Each 0.5 mL PFS contains:
| Component | Quantity | Notes |
|---|---|---|
| ACTIVE INGREDIENT | ||
| Purified Vi Capsular Polysaccharide of Salmonella typhi Ty2 | 25 μg | Conjugated to Tetanus Toxoid - T-cell dependent response |
| CARRIER PROTEIN | ||
| Tetanus Toxoid | 25 μg | Carrier protein - drives immunological memory via T-helper cells |
| EXCIPIENTS | ||
| Sodium Chloride I.P. | 4.5 mg | Tonicity agent |
| Water for Injections I.P. | q.s. to 0.5 mL | Vehicle |
Same core formulation as Typbar TCV. Enteroshield uses the identical active ingredient - Vi polysaccharide (25 μg) conjugated to Tetanus Toxoid (25 μg) - as Bharat Biotech's own Typbar TCV brand. The difference is branding and marketing partner (Abbott India for Enteroshield vs Bharat Biotech directly for Typbar TCV).
Storage critical: Store at +2C to +8C. Do NOT freeze - discard if frozen. Shake well before use. VacciHub nurses carry Enteroshield in validated cold boxes and verify the Vaccine Vial Monitor indicator before every dose.
Enteroshield - IAP 2024 Vaccination Schedule
| Group | Dose | Age / Timing | Notes |
|---|---|---|---|
| Infants (routine) | 1 Dose | 9-12 months | IAP extended immunisation schedule |
| Booster (if under 2 yrs at 1st dose) | Booster | 2 years of age | Required if primary dose given before 2nd birthday |
| Children 2-15 yrs (catch-up) | 1 Dose | Any time | Repeat every 3 years in high-risk areas |
| Adults | 1 Dose | Any time | Repeat every 3 years if continued risk |
| Pre-travel | 1 Dose | 2 or more weeks before travel | Endemic regions: South Asia, Africa, Southeast Asia |
Min age 6 months. Enteroshield is approved from 6 months - the standard first dose per IAP is at 9-12 months alongside other vaccines. Children previously vaccinated with plain Vi polysaccharide vaccine may switch to TCV for improved protection.
How Does Enteroshield Work?
1
Vi-Tetanus Toxoid Conjugate Injected IM
The 0.5 mL PFS delivers purified Vi polysaccharide (25 μg) covalently conjugated to Tetanus Toxoid (25 μg). Administered deep intramuscularly - deltoid in adults/older children, anterolateral thigh in infants.
2
T-Cell Help via Tetanus Toxoid Carrier
The Tetanus Toxoid carrier protein presents the Vi polysaccharide to T-helper cells, converting the immune response from T-independent to T-dependent. This is the critical difference - plain Vi polysaccharide vaccines cannot engage T-cells and thus generate no immunological memory.
3
High-Titre Anti-Vi IgG Antibodies and Memory
The immune system generates robust IgG antibodies against Vi capsular polysaccharide - these coat S. typhi bacteria and enable complement-mediated killing and phagocytosis. Long-lived memory B and T-cells are simultaneously created.
4
Effective from 6 Months - Lasts Years
Protection develops in about 2 weeks. Conjugate technology enables effective vaccination from 6 months - when plain polysaccharide vaccines are completely ineffective. Booster recommended every 3 years for high-risk individuals.
Enteroshield Side Effects
Enteroshield has a strong safety profile. No aluminium adjuvant, no preservatives - one of the cleanest typhoid vaccine formulations available.
Common (Mild, Self-Limiting)
- Injection-site pain / tenderness
- Redness or swelling at site
- Low-grade fever (under 38.5C)
- Irritability / crying (infants)
- Mild fatigue / drowsiness
Rare - Seek Medical Attention
- High fever (over 39C)
- Prolonged crying over 3 hours (infants)
- Extensive limb swelling
- Anaphylaxis (extremely rare)
Apply a cool cloth (not ice) to injection site. Paracetamol may be used for fever/pain per doctor's advice. Observe for 30 minutes post-vaccination - our VacciHub nurses stay and monitor before leaving.
Enteroshield vs Typbar TCV - What's the Difference?
Both are Typhoid Vi Conjugate Vaccines from the same manufacturer. Here's how they compare:
| Feature | Enteroshield | Typbar TCV |
|---|---|---|
| Marketed by | Abbott India Limited | Bharat Biotech (own brand) |
| Manufactured by | Bharat Biotech Intl. Ltd. | Bharat Biotech Intl. Ltd. |
| Active Ingredient | Vi Polysaccharide 25 μg + TT 25 μg | Vi Polysaccharide 25 μg + TT 25 μg |
| Formulation | Identical | Identical |
| Min Age | 6 months | 6 months |
| No Aluminium | Correct | Correct |
| No Preservatives | Correct | Correct |
| Brand Backing | Abbott India (global healthcare major) | Bharat Biotech (domestic leader) |
Bottom line: Enteroshield and Typbar TCV are effectively the same vaccine - same manufacturer, same active ingredients, same formulation. Enteroshield is simply Bharat Biotech's TCV platform marketed through Abbott India's distribution network. Your doctor or VacciHub nurse can advise on availability.
Precautions and Contraindications
Do NOT give Enteroshield if:
- Known hypersensitivity to any component, including Tetanus Toxoid
- Severe allergic reaction to a prior TCV or Vi vaccine dose
- Acute febrile illness on vaccination day - defer until recovery
Use with Caution:
- Immunosuppressed individuals - immune response may be reduced; still recommended
- Pregnancy - consult doctor; benefit generally outweighs risk for endemic area residents or travellers
- Recent Tetanus Toxoid-containing vaccine - discuss timing with doctor
- Thrombocytopenia or coagulation disorders - injection-site bleeding risk
Never freeze. Freezing irreversibly destroys Enteroshield's efficacy. Check the Vaccine Vial Monitor before use - VacciHub nurses are trained on cold chain verification at every home visit.
Why Book Enteroshield with VacciHub?
Certified Nursing Staff
Trained, certified nurses with paediatric and adult vaccination experience. Correct deep IM technique for every age group.
Cold Chain - Never Frozen
Enteroshield must NEVER be frozen. Our validated cold boxes maintain exactly 2-8C. Potency guaranteed from warehouse to your arm.
100% Genuine Abbott / Bharat Biotech
Sourced from authorised distributors only. Batch numbers, MFG and EXP dates fully transparent and verifiable.
Home Comfort
No hospital trips, no queues. Our nurse comes to you - especially convenient for infants, toddlers and busy working families.
Digital Vaccination Record
Batch number, expiry, dose details shared via WhatsApp post-visit. Booster reminders set automatically.
Same-Day and Weekend Slots
Flexible bookings morning to evening including weekends. Pre-travel at short notice? Same-day available across Delhi NCR.
Enteroshield Home Vaccination - Cities We Cover
🏛️Delhi (All Areas)
🏙️Gurgaon
🌅Noida
🏠Ghaziabad
🏗️Faridabad
🌚Greater Noida
Call +91 92050 04114 to confirm your pincode. Same-day slots available.
Frequently Asked Questions - Enteroshield Vaccine
Enteroshield is a Typhoid Vi Conjugate Vaccine IP (TCV) marketed by Abbott India Limited and manufactured by Bharat Biotech International Limited, Hyderabad. It contains purified Vi Capsular Polysaccharide of Salmonella typhi Ty2 conjugated to Tetanus Toxoid (25 μg), providing T-cell-dependent immunity against typhoid fever from 6 months of age.
Yes - both Enteroshield and Typbar TCV are manufactured by Bharat Biotech and contain the identical formulation: Vi polysaccharide 25 μg conjugated to Tetanus Toxoid 25 μg. Enteroshield is simply Bharat Biotech's typhoid conjugate vaccine marketed under the Abbott India brand name and distribution network.
Enteroshield can be given from 6 months of age. IAP 2024 recommends the first dose at 9-12 months as part of the extended immunisation schedule. A booster is given at 2 years if the primary dose was administered before the 2nd birthday.
Common side effects are mild: injection-site pain, redness, swelling, low-grade fever and irritability in infants - resolving in 1-3 days. Enteroshield contains no aluminium adjuvant and no preservatives, contributing to its excellent tolerability. Serious adverse events are extremely rare.
Absolutely. VacciHub provides home vaccination with genuine Enteroshield across Delhi, Gurgaon, Noida, Ghaziabad, Faridabad and Greater Noida. Our nurses maintain cold chain (2-8C, never frozen) throughout. Call +91 92050 04114 or WhatsApp to book.
After the primary series, a booster every 3 years is recommended for those in high-risk areas or with travel/occupational exposure. For pre-travel vaccination, a single dose 2 or more weeks before departure provides adequate short-term protection.
Yes - Enteroshield must be stored at +2C to +8C at all times. Never freeze. Freezing destroys the vaccine's efficacy and it must be discarded if frozen. VacciHub transports Enteroshield in validated cold boxes with temperature monitoring. Our nurses check the Vaccine Vial Monitor indicator before every administration.