Rx
🏭 Serum Institute (SII)
❄️ Cold Chain
🛡️ 10-Valent (PCV10)
🌐 WHO Prequalified
🇮🇳 Made in India
Pneumosil® · Serum Institute of India (SII) · 0.5 mL Single Dose Vial · Intramuscular
Composition · 10 Serotypes · CRM197 Carrier · Al-Phosphate 0.125mg · Store 2–8°C · Shake Well · Not to be Frozen
🛡️ Pneumococcal Diseases Pneumosil Protects Against
Pneumococcal Pneumonia
Streptococcus pneumoniae is the leading bacterial cause of pneumonia in children under 5. Causes high fever, breathing difficulty and can be fatal. 10 Pneumosil serotypes cover the majority of pneumonia-causing strains in India.
Bacterial Meningitis
Pneumococcal meningitis has a case fatality rate of 20–30% and leaves 30–50% of survivors with permanent disabilities — hearing loss, brain damage, learning difficulties. Vaccine prevention is the most effective strategy.
Septicaemia (Bloodstream Infection)
Invasive pneumococcal disease (IPD) causing bacteraemia/sepsis. Rapid onset, high mortality in young infants. Pneumosil's conjugate technology provides strong protection against invasive disease.
Acute Otitis Media (Ear Infections)
Pneumococcus is a leading cause of middle ear infections in children — a common reason for antibiotic prescriptions. Vaccination reduces the frequency and severity of ear infections and antibiotic dependence.
Sinusitis & Acute Febrile Illness
Pneumococcal sinusitis and febrile illnesses are common causes of hospitalisation in young children. Reducing pneumococcal carriage through vaccination lowers the overall burden of respiratory illness.
Antibiotic-Resistant Strains
Several Pneumosil serotypes (19A, 6B, 23F) are among the most antibiotic-resistant pneumococcal strains globally. Vaccination prevents disease before antibiotic resistance becomes an issue.
👥 Who Should Get Pneumosil?
Infants (Primary Series) ⭐
Primary target: all infants from 6 weeks of age. IAP 2024 recommends PCV as part of the routine infant immunisation schedule. Pneumosil is the affordable Indian alternative to imported PCV vaccines.
Premature & Low Birth Weight Babies
Preterm infants (<37 weeks) and low birth weight babies have immature immune systems and are at higher risk of severe pneumococcal disease. PCV is strongly recommended — immunise at chronological age regardless of gestational age.
Children with Chronic Conditions
Congenital heart disease, chronic lung disease, liver/kidney disease, diabetes. All increase susceptibility to invasive pneumococcal disease. PCV is especially important for these children.
Immunocompromised Children
HIV-positive infants, children with asplenia (no spleen), on immunosuppressants or receiving chemotherapy. At dramatically elevated risk for fatal IPD. Pneumosil is an inactivated vaccine — safe for all these groups.
Adults 65+ (Catch-up)
Pneumococcal disease is also a leading cause of hospitalisation and death in the elderly. Adults 65+ who have not previously received PCV should discuss vaccination with their doctor.
Catch-Up Vaccination
Children who missed their primary PCV series can receive catch-up doses. The catch-up schedule depends on age at first dose — call VacciHub and our nurses will advise on the appropriate catch-up regimen.
🔬 Pneumosil Composition – Per 0.5 mL Dose
As per Serum Institute of India manufacturer label. Each 0.5 mL single-dose vial contains:
| Component | Quantity | Notes |
|---|---|---|
| ACTIVE INGREDIENTS – 10 PNEUMOCOCCAL SEROTYPES | ||
| Saccharide for serotypes 1, 5, 9V, 14, 19A, 19F, 23F, 7F, 6A (9 serotypes) | 2 mcg each | Polysaccharide of each serotype, individually conjugated to CRM197 |
| Saccharide for serotype 6B | 4 mcg | Double dose — 6B is a major disease-causing serotype requiring higher antigen content |
| CARRIER PROTEIN | ||
| CRM197 (Cross-Reactive Material 197) | 19 to 48 mcg | Non-toxic diphtheria toxin mutant — T-cell dependent carrier protein for all 10 conjugates |
| ADJUVANT & EXCIPIENTS | ||
| Aluminium (as Aluminium phosphate) | 0.125 mg | Adjuvant — enhances and prolongs immune response |
| Sucrose | q.s. | Stabiliser |
| Sodium chloride | q.s. | Tonicity agent |
| Water for injections | q.s. to 0.5 mL | Vehicle |
💡 CRM197 Carrier Protein: All 10 polysaccharides are individually conjugated to CRM197 — a non-toxic mutant of diphtheria toxin. CRM197 is the same carrier used in Prevenar 13 (PCV13). It recruits T-helper cells (CD4+), generating T-cell-dependent immunological memory — the critical advantage of conjugate over plain polysaccharide vaccines.
⚠️ Storage: 2–8°C. NOT TO BE FROZEN. SHAKE WELL before administration (aluminium adjuvant settles). Meets W.H.O. requirements. VacciHub nurses shake the vial before every injection and verify cold chain before each dose.
📅 Pneumosil – IAP 2024 Immunisation Schedule
Two schedules are recommended by IAP 2024:
| Schedule | Dose | Age | Notes |
|---|---|---|---|
| 3+1 SCHEDULE (Standard – EPI Schedule) | |||
| 3+1 | Dose 1 | 6 weeks | First dose — earliest age |
| Dose 2 | 10 weeks | 4 weeks after Dose 1 | |
| Dose 3 | 14 weeks | 4 weeks after Dose 2 | |
| Booster | 12–15 months | ⭐ Critical — booster completes immunity | |
| 2+1 SCHEDULE (Alternative) | |||
| 2+1 | Dose 1 | 2 months | Minimum 8 weeks between doses |
| Dose 2 | 4 months | 2 months after Dose 1 | |
| Booster | 12 months | ⭐ At least 6 months after Dose 2 | |
⚠️ Booster is essential. The booster dose at 12–15 months is critical for long-term protection. Studies show significant antibody waning after the primary series — the booster restores and consolidates immunity. Do not miss it. VacciHub sends WhatsApp reminders for all follow-up doses.
ℹ️ Catch-up schedule: If primary vaccination was missed, a catch-up schedule can be initiated at any age up to 5 years. The number of doses depends on the child's current age. Call VacciHub for a personalised catch-up plan.
⚙️ How Does Pneumosil Work?
1
10 Polysaccharide–CRM197 Conjugates Injected IM
After gentle shaking, 0.5 mL is injected intramuscularly into the anterolateral thigh (infants) or deltoid (older children/adults). The dose delivers 10 individual polysaccharide–CRM197 conjugates — one for each pneumococcal serotype — adsorbed on aluminium phosphate adjuvant.
2
CRM197 Activates T-Cell-Dependent Immunity
The CRM197 carrier recruits T-helper cells (CD4+) for each conjugate. This converts the immune response from T-independent (plain polysaccharide) to T-dependent — enabling true immunological memory, effective from 6 weeks of age, and a booster response on subsequent doses.
3
Serotype-Specific Anti-Capsular Antibodies
The immune system generates IgG antibodies against the capsular polysaccharide of each of the 10 serotypes. These antibodies bind pneumococcal bacteria, activate complement and facilitate phagocytosis — preventing invasive disease and reducing nasopharyngeal carriage.
4
Herd Immunity Effect
By reducing pneumococcal carriage in vaccinated children, PCV vaccination also protects unvaccinated contacts (elderly, immunocompromised) through indirect herd immunity — a unique benefit of childhood PCV programmes demonstrated globally.
⚠️ Pneumosil Side Effects
Pneumosil has a well-established safety profile. Side effects are generally mild and transient.
🟡 Common (Mild, 1–3 Days)
- 💉 Injection-site pain / tenderness
- 🔴 Redness or swelling at site
- 🌡️ Low-grade fever (<38.5°C)
- 😢 Irritability / crying (infants)
- 😴 Drowsiness / poor feeding
- 😴 Mild fatigue
🔴 Rare – Seek Medical Attention
- 🤒 High fever (>39°C)
- 😢 Prolonged crying >3 hours
- ⚡ Febrile seizure (rare)
- 🚨 Anaphylaxis (extremely rare)
💡 Apply a clean cool cloth (not ice) to the injection site. Paracetamol may be given for fever/pain per your paediatrician's advice. Our VacciHub nurses observe the baby for 30 minutes before leaving every home visit.
⚖️ Pneumosil (PCV10) vs Prevenar 13 (PCV13) – Comparison
| Feature | Pneumosil (PCV10) | Prevenar 13 (PCV13) |
|---|---|---|
| Manufacturer | ✓ SII (India) – WHO PQ'd 2020 | Pfizer (USA) – WHO PQ'd |
| Valency | 10 serotypes | ✓ 13 serotypes |
| Serotypes in common | 1, 5, 6B, 7F, 9V, 14, 19F, 23F (8 shared) | |
| Serotype 6A | ✓ Included (2 mcg) | ✗ Not included |
| Serotype 19A | ✓ Included (2 mcg) | ✓ Included |
| Serotypes 3, 4, 18C | ✗ Not included | ✓ Included (PCV13 only) |
| Carrier protein | CRM197 (same as PCV13) | ✓ CRM197 |
| Adjuvant | Aluminium phosphate 0.125 mg | Aluminium phosphate 0.125 mg |
| Made in India | ✓ Yes — Pune, Maharashtra | No (imported) |
| Price point | ✓ More accessible | Higher (imported) |
| WHO requirements | ✓ Meets WHO requirements | ✓ Yes |
| IAP recommendation | ✓ Accepted | ✓ Accepted |
ℹ️ Key point: Pneumosil uniquely includes serotype 6A (absent in standard PCV10/Synflorix) and 19A, giving it broader coverage than classic PCV10. Prevenar 13 additionally covers serotypes 3, 4 and 18C. Both vaccines are WHO-approved and IAP-recommended. Your paediatrician can guide the best choice for your child.
🚫 Precautions & Contraindications
Do NOT give Pneumosil if:
- Known hypersensitivity to any component including CRM197 or aluminium phosphate
- Severe allergic reaction to a prior Pneumosil or PCV dose
- Acute moderate-to-severe febrile illness on vaccination day — defer until recovery
Use with Caution:
- Immunosuppressed children — immune response may be reduced; PCV still strongly recommended
- Coagulation disorders — use fine needle, apply firm pressure at injection site
- Do NOT inject intravenously or intradermally — intramuscular only
- Do NOT mix with other vaccines in the same syringe
⚠️ NOT TO BE FROZEN. SHAKE WELL before use — the aluminium phosphate adjuvant settles on standing. Do not use if the vaccine has been frozen or if particulate matter is visible after shaking. VacciHub nurses verify all these checks at every home visit.
🏥 Why Book Pneumosil with VacciHub?
Certified Paediatric Nurses
Trained nurses experienced in infant vaccination. Correct anterolateral thigh IM injection for babies. Proper shake-before-use protocol followed every time.
Cold Chain — Never Frozen
Pneumosil must NEVER be frozen. Our validated cold boxes maintain 2–8°C throughout. Temperature verified before every dose administration.
100% Genuine SII Pneumosil
Sourced from authorised SII distributors. Batch numbers and expiry dates fully transparent on your WhatsApp vaccination record.
Home Comfort for Infants
No hospital queues, no infection risk in waiting rooms. Your baby stays in the comfort of home — calmer, less stressed, safer. Especially important for immunocompromised infants.
Full Series Tracking
We track all 3 primary doses AND the booster, sending WhatsApp reminders for each due date. Never miss a dose in the PCV series.
Same-Day & Weekend Slots
Flexible morning to evening slots including weekends. Multiple vaccines can be administered in the same visit (at different sites) to minimise visits.
📍 Pneumosil Home Vaccination – Cities We Cover
🏛️Delhi (All Areas)
🏙️Gurgaon
🌆Noida
🏘️Ghaziabad
🏗️Faridabad
🌇Greater Noida
Call +91 92050 04114 to confirm your area — same-day slots available.
❓ Frequently Asked Questions – Pneumosil
Pneumosil is a Pneumococcal Polysaccharide Conjugate Vaccine (Adsorbed) 10-Valent by the Serum Institute of India (SII). It protects against 10 pneumococcal serotypes (1, 5, 6A, 6B, 7F, 9V, 14, 19A, 19F, 23F) responsible for the majority of childhood pneumococcal pneumonia, bacterial meningitis, septicaemia and acute otitis media (ear infections) in India. It is the first Made-in-India PCV to receive WHO prequalification (2020).
3+1 Schedule (standard): Dose 1 at 6 weeks, Dose 2 at 10 weeks, Dose 3 at 14 weeks, Booster at 12–15 months.
2+1 Schedule (alternative): Dose 1 at 2 months, Dose 2 at 4 months, Booster at 12 months.
The booster at 12–15 months is critical for long-term protection. VacciHub sends WhatsApp reminders for each dose.
2+1 Schedule (alternative): Dose 1 at 2 months, Dose 2 at 4 months, Booster at 12 months.
The booster at 12–15 months is critical for long-term protection. VacciHub sends WhatsApp reminders for each dose.
Both use CRM197 carrier protein and aluminium phosphate adjuvant. Key differences: Pneumosil covers 10 serotypes including 6A (unique to Pneumosil among PCV10s) and 19A. Prevenar 13 covers 13 serotypes including 3, 4 and 18C (not in Pneumosil). Pneumosil is Made in India (SII) at a more accessible price. Prevenar 13 is imported (Pfizer). Both are WHO-approved and IAP-recommended. Your paediatrician can advise on the best choice.
Yes. Pneumosil received WHO prequalification in 2020 — making it the first Made-in-India pneumococcal conjugate vaccine to achieve this milestone globally. It also meets WHO requirements as stated on the manufacturer label. This enables its use in GAVI-supported programmes worldwide.
Yes. VacciHub provides home vaccination with genuine SII Pneumosil across Delhi, Gurgaon, Noida, Ghaziabad, Faridabad and Greater Noida. Our certified nurses shake the vial before use, administer correct IM injection and follow the full 3-dose + booster schedule with reminders. Call +91 92050 04114 or WhatsApp to book.
Common side effects are mild: injection-site pain, redness, swelling, low-grade fever, irritability and drowsiness in infants — all resolving within 1–3 days. Serious adverse events are very rare. Paracetamol may be given for fever/pain as per your paediatrician's advice. Our VacciHub nurses observe babies for 30 minutes post-vaccination.
Antibody levels after the primary 3-dose series wane significantly by 12 months. The booster dose at 12–15 months triggers a powerful anamnestic (memory) immune response — generating high antibody titres that provide long-term protection well beyond the toddler years. Studies show the booster is essential for preventing disease in the second year of life and beyond. This is why VacciHub actively tracks and reminds you for the booster.