Rx
🏭 Pfizer
❄️ Cold Chain
🛡️ 13-Valent (PCV13)
🌍 Imported (Belgium)
13 Serotypes · CRM197 Carrier ~32 µg · Al-Phosphate 0.125mg · Store 2–8°C · Do Not Freeze · Mfg: Pfizer, Belgium
⚖️ Prevenar 13 vs Other Available PCVs – At a Glance
⭐ This Page
13
Prevenar 13
Pfizer (imported)
CRM197 carrier
Al-phosphate 0.125mg
CRM197 carrier
Al-phosphate 0.125mg
Global gold standard
Widest track record
Widest track record
Broadest
14
PneuBevax 14
Biological E (India)
CRM197 carrier
Al-phosphate ≤0.75mg
CRM197 carrier
Al-phosphate ≤0.75mg
+ Serotypes 22F & 33F
Made in India
Made in India
Affordable
10
Synflorix / Pneumosil
GSK / SII
Protein D or CRM197
Most affordable
Protein D or CRM197
Most affordable
10 serotypes
Lower cost option
Lower cost option
💡 The Gold Standard Advantage: Prevenar 13 has the longest real-world track record of any PCV, backed by over a decade of use in national immunisation programmes across more than 100 countries, including the UK, USA and India's private market. Its extensive safety and efficacy data make it a trusted first choice for many paediatricians.
🛡️ Pneumococcal Diseases Prevenar 13 Protects Against
Pneumococcal Pneumonia
Streptococcus pneumoniae is the #1 bacterial cause of pneumonia in children and adults. Prevenar 13's 13 serotypes cover the strains most responsible for pneumonia in India and globally.
Bacterial Meningitis
Pneumococcal meningitis — 20–30% fatality rate, 30–50% survivors with permanent disabilities. Multiple Prevenar 13 serotypes (1, 3, 6A, 6B, 14, 19A, 23F) are major meningitis-causing strains.
Septicaemia / Bacteraemia
Invasive pneumococcal bloodstream infection — high mortality in young infants and elderly. Serotypes 1, 3, 4, 14, 18C, 19A, 19F are common causes of invasive disease — all covered by Prevenar 13.
Acute Otitis Media & Sinusitis
Pneumococcus causes most bacterial ear infections in children — the #1 reason for antibiotic prescriptions. Prevenar 13's broad serotype coverage helps reduce recurrent ear infections.
🌍 Global Gold Standard: Prevenar 13 has been used in national immunisation programmes in over 100 countries for more than a decade, with an extensive body of real-world safety and efficacy data supporting its use across all age groups from infants to elderly adults.
👥 Who Should Get Prevenar 13
All Infants from 6 Weeks ⭐
Primary target: all infants from 6 weeks of age. PCV vaccination is IAP 2024 recommended routine infant immunisation. Prevenar 13 is the world's most widely used PCV.
Premature & High-Risk Infants
Premature and low-birth-weight babies are at higher risk of invasive pneumococcal disease and benefit strongly from timely PCV vaccination starting at 6 weeks.
Immunocompromised Children
HIV-positive, asplenic, on chemotherapy or immunosuppressants — at high risk for IPD from any serotype. Prevenar 13 is inactivated — safe for all these groups.
Adults 65+ (Catch-Up)
Elderly adults with chronic diseases (COPD, heart disease, diabetes, kidney disease) at high risk for pneumococcal pneumonia. Prevenar 13 is licensed for adults and is a globally recommended adult PCV.
Families Wanting the Established Choice
Parents and adults who prefer a PCV with the longest global usage history and the most extensive published safety and efficacy data.
🔬 Prevenar 13 Composition – Per 0.5 mL Dose
As per Pfizer manufacturer label. Each 0.5 mL single-dose pre-filled syringe contains:
| Component | Quantity | Notes |
|---|---|---|
| SEROTYPES 1, 3, 4, 5, 6A, 7F, 9V, 14, 18C, 19A, 19F, 23F (Standard Dose) | ||
| Pneumococcal Polysaccharide serotypes 1, 3, 4, 5, 6A, 7F, 9V, 14, 18C, 19A, 19F, 23F | 2.2 µg each | 12 serotypes at standard dose |
| SEROTYPE 6B (Higher Dose) | ||
| Pneumococcal Polysaccharide serotype 6B | 4.4 µg | Double the standard dose — 6B requires higher antigen content |
| CARRIER PROTEIN AND ADJUVANT | ||
| CRM197 carrier protein | ~32 µg | Non-toxic diphtheria toxin mutant. Each polysaccharide individually conjugated. |
| Aluminium (as Aluminium Phosphate) | 0.125 mg Al+++ | Adjuvant — enhances and prolongs immune response |
| INACTIVE INGREDIENTS | ||
| Sodium Chloride, Succinic Acid, Polysorbate 80, Water for Injection | — | Contains no preservative |
💡 CRM197 — Trusted Carrier: Prevenar 13 uses CRM197 (non-toxic diphtheria toxin mutant) carrier protein — the same trusted carrier technology used across multiple pneumococcal conjugate vaccines. Each of the 13 polysaccharides is individually conjugated, generating T-cell-dependent immunity and immunological memory from 6 weeks of age.
⚠️ Store between 2°C to 8°C. Do not freeze. Shake well before use. Supplied as a single-dose pre-filled syringe with a separate needle (not pre-attached). VacciHub nurses attach the needle and verify batch/expiry before every injection.
📅 Prevenar 13 – IAP 2024 Vaccination Schedule
| Schedule | Dose | Age | Notes |
|---|---|---|---|
| 3+1 SCHEDULE (Standard) | |||
| 3+1 | Dose 1 | 6 weeks | Earliest recommended age |
| Dose 2 | 10 weeks | Minimum 4 weeks from Dose 1 | |
| Dose 3 | 14 weeks | Minimum 4 weeks from Dose 2 | |
| Booster | 12–15 months | ⭐ Critical — restores waning immunity | |
| 2+1 SCHEDULE (Alternative) | |||
| 2+1 | Dose 1 | 2 months | Min 8 weeks between doses |
| Dose 2 | 4 months | 2 months after Dose 1 | |
| Booster | 12 months | ⭐ Min 6 months after Dose 2 | |
ℹ️ Catch-up vaccination: Children who missed the primary PCV series can receive catch-up doses up to 5 years of age. Schedule depends on current age. Call VacciHub for a personalised catch-up plan. Adults 65+ with chronic conditions receive a single dose.
⚠️ The booster at 12–15 months is critical — antibody levels from the primary series wane significantly by 12 months. The booster triggers a powerful memory response. VacciHub sends WhatsApp reminders for all PCV doses.
⚙️ How Does Prevenar 13 Work?
1
Intramuscular Injection
Prevenar 13 is injected intramuscularly (anterolateral thigh in infants, deltoid in older children/adults). The dose delivers 13 individual pneumococcal polysaccharide–CRM197 conjugates adsorbed on aluminium phosphate adjuvant.
2
CRM197 Recruits T-Helper Cells (T-Dependent Immunity)
The CRM197 carrier protein activates CD4+ T-helper cells for each of the 13 conjugates simultaneously. This generates T-cell-dependent immune responses — creating true immunological memory, effective from 6 weeks, and an amplified booster response on subsequent doses.
3
13 Serotype-Specific IgG Antibodies Produced
The immune system generates protective IgG antibodies against all 13 pneumococcal serotypes. These antibodies bind pneumococcal bacteria, activate complement and facilitate opsonophagocytic killing, preventing invasive disease.
4
Herd Protection + Nasopharyngeal Carriage Reduction
PCV vaccination reduces pneumococcal nasopharyngeal colonisation — the source of spread. Vaccinated children are less likely to carry and transmit pneumococcus to unvaccinated contacts (elderly, immunocompromised), creating indirect herd protection — a key reason Prevenar 13's widespread global use has reduced disease even in unvaccinated populations.
⚠️ Prevenar 13 Side Effects
Prevenar 13 has one of the most well-established safety profiles of any PCV, backed by over a decade of global use.
🟡 Common (Mild, 1–3 Days)
- 💉 Injection-site pain / tenderness
- 🔴 Redness or swelling at site
- 🌡️ Low-grade fever (<38.5°C)
- 😢 Irritability / crying (infants)
- 😴 Drowsiness / poor appetite
🔴 Rare – Seek Medical Attention
- 🤒 High fever (>39°C)
- 😢 Prolonged crying >3 hours
- ⚡ Febrile seizure (rare)
- 🚨 Anaphylaxis (extremely rare)
💡 Apply a cool cloth to the injection site. Paracetamol as per your paediatrician's advice. Our VacciHub nurses observe babies for 30 minutes post-vaccination and advise on fever management before leaving.
⚖️ Prevenar 13 (PCV13) vs PneuBevax 14 (PCV14) – Detailed Comparison
| Feature | Prevenar 13 (PCV13) | PneuBevax 14 (PCV14) |
|---|---|---|
| Marketed by | Pfizer (imported) | Biological E (Indian brand) |
| Manufactured by | Pfizer, Belgium | Biological E, Hyderabad |
| Serotypes covered | 13 | ✓ 14 |
| Carrier protein | ✓ CRM197 | ✓ CRM197 (same) |
| Serotype 22F | ✗ Not included | ✓ Included (2.2 µg) |
| Serotype 33F | ✗ Not included | ✓ Included (2.2 µg) |
| Al-Phosphate adjuvant | 0.125 mg | ≤ 0.75 mg |
| Presentation | Pre-filled syringe + separate needle | Vial + syringe + 2 needles |
| Made in India | No – imported | ✓ Yes – Hyderabad |
| Track record | ✓ 100+ countries, over a decade | Newer to Indian market |
| IAP recommendation | ✓ Standard | ✓ Accepted |
✅ Key advantage of Prevenar 13: The longest global track record of any PCV, with extensive published safety and efficacy data across over 100 countries. PneuBevax 14, in turn, offers broader serotype coverage with 2 additional serotypes (22F, 33F) and is made in India. Your paediatrician can help you choose the best fit.
🚫 Precautions & Contraindications
Do NOT give Prevenar 13 if:
- Known hypersensitivity to any component including CRM197 or aluminium phosphate
- Severe allergic reaction to a prior PCV dose
- Acute moderate-to-severe febrile illness — defer until recovery
Use with Caution:
- Immunosuppressed patients — immune response may be reduced; PCV still strongly recommended
- Coagulation disorders — use fine needle, firm pressure post-injection
- Do NOT mix with other vaccines in the same syringe
- IM administration only — not IV or intradermal
⚠️ Do NOT freeze. Shake well before use. The needle is supplied separately from the pre-filled syringe — VacciHub nurses attach it correctly and verify batch/expiry before every injection.
🏥 Why Book Prevenar 13 with VacciHub?
Certified Paediatric Nurses
Trained nurses experienced in infant and adult vaccination. Correct IM injection technique and needle attachment. Pre-vaccination health check and 30-minute post-vaccination observation included.
Cold Chain — Never Frozen
Prevenar 13 must NEVER be frozen. Our validated cold boxes maintain 2–8°C throughout. Temperature verified before every dose administration.
Genuine Pfizer Sourcing
Sourced from authorised Pfizer distributors only. Batch numbers and needle pack details fully verified and shared on your WhatsApp vaccination record.
Home Comfort
No hospital queues, no infection-risk waiting rooms. Your baby stays calm and safe at home. Especially convenient for infants and families with multiple children.
Full Series + Booster Tracking
We track all 3 primary doses and the 12–15 month booster, sending WhatsApp reminders for each. Never miss a dose in the PCV series.
Flexible & Same-Day Slots
Morning to evening, weekends included. Multiple vaccines administered in the same visit at different sites — minimising visits.
📍 Prevenar 13 Home Vaccination – Cities We Cover
🏛️Delhi (All Areas)
🏙️Gurgaon
🌆Noida
🏘️Ghaziabad
🏗️Faridabad
🌇Greater Noida
Call +91 92050 04114 to confirm your area — same-day slots available.
❓ Frequently Asked Questions – Prevenar 13
Prevenar 13 is a 13-valent Pneumococcal Conjugate Vaccine (PCV13) manufactured by Pfizer, Belgium and imported & marketed in India by Pfizer Limited. It covers 13 pneumococcal serotypes and is the world's most widely used PCV. PneuBevax 14 covers the same 13 serotypes plus 2 additional ones (22F, 33F) and is made in India.
Prevenar 13 contains: Serotypes 1, 3, 4, 5, 6A, 7F, 9V, 14, 18C, 19A, 19F, 23F (2.2 µg each), and Serotype 6B (4.4 µg). All are individually conjugated to CRM197 carrier protein (~32 µg total) and adsorbed on Aluminium Phosphate (0.125 mg Al+++).
3+1 (standard): Dose 1 at 6 weeks, Dose 2 at 10 weeks, Dose 3 at 14 weeks, Booster at 12–15 months.
2+1 (alternative): Dose 1 at 2 months, Dose 2 at 4 months, Booster at 12 months.
The booster is critical — antibodies wane and the booster restores high-level memory immunity. VacciHub tracks and reminds for all doses.
2+1 (alternative): Dose 1 at 2 months, Dose 2 at 4 months, Booster at 12 months.
The booster is critical — antibodies wane and the booster restores high-level memory immunity. VacciHub tracks and reminds for all doses.
Prevenar 13 is manufactured by Pfizer Manufacturing Belgium NV, Rijksweg 12, Puurs, Belgium, and imported and marketed in India by Pfizer Limited, Bandra Kurla Complex, Mumbai. Prevenar 13 is a registered trademark of Pfizer Inc.
Yes. Prevenar 13 is licensed and recommended for adults, including those 65 years and older with chronic conditions (COPD, heart disease, diabetes, kidney disease) who are at higher risk of pneumococcal pneumonia. Adults typically receive a single dose.
Yes. VacciHub provides home vaccination with genuine Prevenar 13 across Delhi, Gurgaon, Noida, Ghaziabad and Faridabad and Greater Noida. Our certified nurses attach the separate needle correctly, shake the syringe well, and follow post-vaccination monitoring. Call +91 92050 04114 or WhatsApp to book.