Rx
🏭 Bharat Biotech
❄️ Cold Chain
🧬 rDNA – No Live Virus
🇮🇳 Made in India
⚠️ Schedule H
📦 Box – Front
Revac-B+® · Bharat Biotech · 1 mL Single Dose Vial (Adult)
🔬 Composition – Side Label
HBsAg ≥20 µg · Al(OH)₃ 0.5 mg · Thiomersal 0.05 mg · DO NOT FREEZE
🦠 About Hepatitis B – Why Vaccinate?
Chronic Liver Disease & Cancer
Hepatitis B is a major cause of chronic liver disease, cirrhosis and hepatocellular carcinoma (liver cancer). ~300 million people worldwide have chronic HBV infection. India has ~40 million chronic carriers — one of the highest globally.
Perinatal Transmission — #1 Route
The most common HBV transmission route in India is mother to newborn at birth. Infants infected perinatally have a 90% risk of developing chronic HBV. The birth dose within 24 hours is the most critical intervention.
95% Effective – Lifelong Protection
The complete 3-dose series generates anti-HBs antibodies in 95% of recipients and provides lifelong protection. Hepatitis B vaccine is the only approved vaccine that can prevent liver cancer — a unique distinction.
Why rDNA – Recombinant?
rDNA vaccines express HBsAg in yeast (Saccharomyces cerevisiae) using recombinant DNA technology — producing highly pure HBsAg protein with no risk of HBV infection. Revac-B+ uses this technology, guaranteeing safety and consistent antigen quality.
👥 Who Should Get Revac-B+?
All Newborns — Birth Dose ⭐
The most critical use. First dose within 24 hours of birth is essential to prevent perinatal HBV transmission. IAP 2024 mandates HepB birth dose for all newborns. VacciHub provides birth dose vaccination at home within hours of delivery.
Infants – Primary Series
Doses 2, 3, 4 come as part of the 6-in-1 combination vaccine (Hexasiil) at 6, 10, 14 weeks. Revac-B+ is used as a standalone birth dose (Dose 1) before the 6-in-1 series begins.
Children – Catch-Up
Unvaccinated or incompletely vaccinated children. Catch-up schedule: 3 doses at 0, 1, 6 months. Any child who did not receive birth dose or complete infant series needs catch-up.
Healthcare Workers
High occupational exposure risk. Pre-exposure vaccination with 3-dose adult schedule (1 mL doses at 0, 1, 6 months) is mandatory for healthcare workers. Anti-HBs titre check recommended after series.
Dialysis & Immunocompromised
Dialysis patients, HIV patients, organ transplant recipients — at high risk for blood-borne HBV. May need double-dose schedule (40 µg, 2 vials per dose) and titre monitoring as immune response may be reduced.
Household Contacts of HBsAg+ Persons
Close contacts of HBV carriers — spouses, family members sharing utensils — are at transmission risk. Vaccination plus anti-HBs titre check within 1–2 months of completing series.
International Travellers
Travel to Southeast Asia, Sub-Saharan Africa — HBV endemic regions. Ensure complete 3-dose series is done before travel. Accelerated schedules (0, 1, 2 months + booster at 12 months) available for urgent travel.
Unvaccinated Adults
Any adult who has never been vaccinated against Hepatitis B. Adults born before the 1990s HepB programme in India are likely unvaccinated. A simple 3-dose adult series provides lifelong protection.
🔬 Revac-B+ Composition – Per 1 mL Adult Dose
As per Bharat Biotech manufacturer label. Each 1 mL contains:
| Component | Quantity | Role |
|---|---|---|
| ACTIVE INGREDIENT | ||
| Purified HBsAg (Hepatitis B Surface Antigen) | ≥ 20 µg | Recombinant antigen produced in yeast (rDNA). Stimulates anti-HBs antibody response. No live virus. |
| ADJUVANT | ||
| Aluminium Hydroxide gel (Al+++ equivalent) | 0.5 mg | Aluminium adjuvant — depot effect at injection site, prolongs antigen presentation, enhances antibody response |
| PRESERVATIVE | ||
| Thiomersal I.P. (as Preservative) | 0.05 mg | Mercury-based preservative in multi-dose vials. Standard for HepB vaccines. Ethylmercury at this dose is considered safe per WHO; cleared from body quickly unlike methylmercury. |
| DOSAGE FORM | ||
| Form | Suspension for IM injection | Shake well — adjuvant settles on standing |
| Route | Intramuscular only | Deltoid (adults) · Anterolateral thigh (infants) |
| Storage | 2°C to 8°C | DO NOT FREEZE · Shake well before use |
💡 Thiomersal — Is it safe? Thiomersal contains ethylmercury (not methyl mercury). Ethylmercury is rapidly cleared from the body and does not accumulate in tissues unlike methylmercury (found in fish). WHO, DCGI and major health authorities confirm thiomersal-containing vaccines are safe. The dose (0.05 mg) is well within established safety limits for all ages including infants.
⚠️ DO NOT FREEZE. Shake well before use. Freezing destroys the aluminium adjuvant–antigen adsorption. Discard if frozen. VacciHub nurses check the vial for freeze indicators before every dose.
📅 Hepatitis B Vaccination Schedule (IAP 2024)
| Dose | Age / Timing | Vaccine | Notes |
|---|---|---|---|
| INFANT PRIMARY SERIES (Total 4 Doses) | |||
| Birth Dose | Within 24 hours of birth | Revac-B+ monovalent (0.5 mL) | Most critical dose — prevents perinatal transmission |
| Dose 2 | 6 weeks | As part of Hexasiil (6-in-1) | HepB component of 6-in-1 combination |
| Dose 3 | 10 weeks | As part of Hexasiil (6-in-1) | HepB component of 6-in-1 combination |
| Dose 4 | 14 weeks | As part of Hexasiil (6-in-1) | Completes 4-dose infant series |
| ADULT / CATCH-UP SCHEDULE (3 Doses) | |||
| Dose 1 | Day 0 | Revac-B+ 1 mL (adult) | Deltoid IM · Healthcare workers, adults, catch-up |
| Dose 2 | 1 month after Dose 1 | Revac-B+ 1 mL | Minimum 4 weeks from Dose 1 |
| Dose 3 | 6 months after Dose 1 | Revac-B+ 1 mL | Complete series · Anti-HBs titre check 1–2 months after |
🚨 Birth dose within 24 hours is critical. Infants born to HBsAg-positive mothers must receive HepB vaccine AND Hepatitis B Immunoglobulin (HBIG) within 12 hours of birth at separate injection sites — this combination prevents perinatal infection in >95% of cases. VacciHub provides birth dose home visits at short notice — call immediately after delivery.
ℹ️ Accelerated schedule for urgent travellers: 0, 1, 2 months + booster at 12 months. Anti-HBs titre ≥10 mIU/mL after completing the series confirms protection. Titre check especially important for healthcare workers and dialysis patients.
⚙️ How Does Revac-B+ (rDNA) Work?
1
rDNA HBsAg + Aluminium Adjuvant Injected IM
After shaking well, dose injected into anterolateral thigh (infants) or deltoid (adults). Purified recombinant HBsAg (≥20 µg) adsorbed on aluminium hydroxide forms a depot at the injection site — slowly releasing antigen for prolonged immune stimulation.
2
HBsAg Recognised as Foreign Antigen
Antigen-presenting cells (APCs) process the HBsAg protein and present it to naive T-helper cells via MHC class II. The aluminium adjuvant activates innate immune pathways, creating an optimal environment for adaptive immune activation.
3
Anti-HBs IgG Antibodies Generated
B-cells differentiate into plasma cells producing anti-HBs IgG antibodies. These antibodies bind to HBsAg on the surface of Hepatitis B virus particles, neutralising them and preventing cell entry. Anti-HBs titre ≥10 mIU/mL = seroprotection.
4
Long-term Memory — Lifelong Protection
Long-lived memory B and T cells are established. After the 3-dose series, 95% of healthy adults achieve seroprotection. Memory persists even as antibody titres decline — a booster dose rapidly restores protective levels. Current evidence suggests lifelong protection from a complete series in healthy individuals.
⚠️ Revac-B+ Side Effects
Revac-B+ has an excellent safety profile — it is one of the most widely used and best-studied vaccines globally.
🟡 Common (Mild, 1–3 Days)
- 💉 Injection-site pain / soreness
- 🔴 Mild redness or swelling
- 🌡️ Low-grade fever
- 😴 Fatigue / malaise
- 🤕 Mild headache
🔴 Rare — Seek Medical Attention
- 🚨 Anaphylaxis (extremely rare)
- 😵 Syncope (fainting) post-injection
- 🤒 High fever (>39°C)
- ⚡ Severe allergic reaction
💡 Apply a cool cloth to the injection site. Paracetamol for fever/pain as per doctor's advice. Our VacciHub nurses monitor for 30 minutes post-injection before leaving every home visit.
🚫 Precautions & Contraindications
Do NOT give Revac-B+ if:
- Known hypersensitivity to yeast or any vaccine component (including thiomersal)
- Anaphylaxis to a prior HepB vaccine dose
- Acute severe febrile illness on vaccination day — defer until recovery
Special Situations:
- Dialysis / immunocompromised: Double dose (40 µg — 2 vials) per injection, titre check after series
- Non-responders: ~5% of healthy adults do not seroconvert after 3 doses; additional doses or double-dose series recommended
- Pregnancy: HepB vaccine is generally safe in pregnancy — benefit vs risk is strongly favourable for HBsAg-negative pregnant women in endemic areas
- Anticoagulants: Fine needle with firm post-injection pressure to minimise bleeding risk
⚠️ DO NOT FREEZE. Shake well before use. Intramuscular injection only — never IV, intradermal or subcutaneous (suboptimal immune response). Deltoid for adults, anterolateral thigh for infants. VacciHub nurses follow correct technique for each age group.
🏥 Why Book Revac-B+ with VacciHub?
Birth Dose at Home
We provide birth dose HepB vaccination within 24 hours of delivery — at home or at your delivery location in Delhi NCR. Call immediately after birth; we respond fast for this critical time-sensitive dose.
Never Frozen Cold Chain
Revac-B+ must NEVER be frozen. Our validated cold boxes maintain exactly 2–8°C. Freeze indicators checked before every dose. Aluminium adjuvant quality preserved throughout.
100% Genuine Bharat Biotech
Sourced from authorised BB distributors only. Batch details transparent on your WhatsApp vaccination record after every dose.
Full Series Tracking
We track birth dose + all follow-up HepB doses (as part of 6-in-1 or standalone) with WhatsApp reminders. Adult 3-dose series tracked at 0, 1, 6 months.
Home Convenience
Avoid hospital queues for routine vaccination. Our nurse comes to your home — especially valuable for newborns, elderly adults and busy healthcare workers needing their occupational HepB series.
Urgent & Same-Day Slots
Birth dose within 24 hours — urgent requests handled with priority. Same-day slots for adults starting catch-up series. Call or WhatsApp any time.
📍 Revac-B+ Home Vaccination – Cities We Cover
🏛️Delhi (All Areas)
🏙️Gurgaon
🌆Noida
🏘️Ghaziabad
🏗️Faridabad
🌇Greater Noida
Call +91 92050 04114 anytime — urgent birth dose requests given priority.
❓ Frequently Asked Questions – Revac-B+
Revac-B+ is a Hepatitis B Vaccine (rDNA) IP by Bharat Biotech. It contains Purified HBsAg ≥20 µg (recombinant, produced in yeast — no live virus), adsorbed on Aluminium Hydroxide gel (0.5 mg Al+++) adjuvant, with Thiomersal 0.05 mg as preservative. It is a suspension for intramuscular injection. Shake well before use.
Infant (total 4 doses): Birth dose within 24 hours (Revac-B+ monovalent) + Doses 2, 3, 4 as part of 6-in-1 at 6, 10, 14 weeks.
Adult / Catch-up (3 doses): 0, 1, 6 months — full 1 mL doses. Anti-HBs titre check 1–2 months after Dose 3 confirms seroprotection (≥10 mIU/mL).
Birth dose is the most critical — prevents perinatal (mother-to-child) transmission, which risks 90% chronic infection in infected newborns.
Adult / Catch-up (3 doses): 0, 1, 6 months — full 1 mL doses. Anti-HBs titre check 1–2 months after Dose 3 confirms seroprotection (≥10 mIU/mL).
Birth dose is the most critical — prevents perinatal (mother-to-child) transmission, which risks 90% chronic infection in infected newborns.
Yes. VacciHub provides birth dose home vaccination across Delhi NCR — within 24 hours of delivery at your home. Call +91 92050 04114 immediately after delivery. We treat birth dose requests with priority and dispatch our certified nurse as fast as possible. Cold chain maintained throughout.
Yes. Thiomersal contains ethylmercury — not methylmercury (the harmful form found in fish). Ethylmercury is rapidly cleared from the body and does not accumulate in tissues. At 0.05 mg per dose, it is well within established WHO and DCGI safety limits for all ages including newborns. WHO, CDC, AAP and IAP have all confirmed thiomersal-containing vaccines are safe. Revac-B+ is used safely in millions of Indian newborns annually.
Get vaccinated now — it's never too late. The adult HepB series is 3 doses: Day 0, 1 month later, 6 months after Dose 1. Revac-B+ adult dose is 1 mL (20 µg HBsAg) per injection into the deltoid. VacciHub tracks your 3-dose series and sends reminders at the correct intervals. Call +91 92050 04114 to book your first dose at home.
The birth dose is the single most important Hepatitis B vaccination dose. HBV-infected mothers can transmit the virus to their newborn during delivery — and infants infected this way have a 90% chance of developing chronic HBV infection (vs only 5% in adults). The birth dose, given within 24 hours, combined with HBIG for infants of HBsAg+ mothers, prevents this perinatal transmission in over 95% of cases.
The 0.5 mL paediatric dose contains 10 µg HBsAg — used for infants and children up to 19 years. The 1 mL adult dose contains 20 µg HBsAg — used for adults ≥20 years, healthcare workers and dialysis patients. Dialysis/immunocompromised patients may need 40 µg (2 vials) per dose. Always follow your doctor's prescribed dose. VacciHub nurses administer the correct dose as prescribed.