Rx
🏭 GSK
❄️ Cold Chain
🛡️ 10-Valent (PCV10)
🌍 Imported (GSK Belgium)
0.5 mL Single Dose Vial · 10 Serotypes + Protein D · Store 2–8°C · Do Not Freeze · Mfg: GlaxoSmithKline Biologicals
Composition · Pneumococcal Polysaccharide Serotypes 1, 5, 6B, 7F, 9V, 14, 23F, 4, 18C, 19F · Protein D Conjugated
⚖️ Synflorix vs Other Available PCVs – At a Glance
⭐ This Page
10
Synflorix
GSK (imported)
Protein D / TT / DT carriers
Al-phosphate 0.5mg
Protein D / TT / DT carriers
Al-phosphate 0.5mg
+ Protein D otitis media protection
Unique in India
Unique in India
Standard
13
Prevenar 13
Pfizer (imported)
CRM197 carrier
Al-phosphate 0.125mg
CRM197 carrier
Al-phosphate 0.125mg
Includes serotypes 3, 6A, 19A
Global gold standard
Global gold standard
Affordable
10
Pneumosil
Serum Institute (SII)
CRM197 carrier
WHO PQ 2020
CRM197 carrier
WHO PQ 2020
Includes 6A and 19A
Most affordable
Most affordable
💡 The Protein D Advantage: Synflorix is the only PCV available in India where most serotypes are conjugated to Protein D, derived from non-typeable Haemophilus influenzae (NTHi). This gives Synflorix additional, documented protection against acute otitis media (ear infections) caused by NTHi — a benefit not shared by CRM197-based vaccines like Prevenar 13 or Pneumosil.
🛡️ Pneumococcal Diseases Synflorix Protects Against
Pneumococcal Pneumonia
Streptococcus pneumoniae is the #1 bacterial cause of pneumonia in children. Synflorix's 10 serotypes cover the strains most responsible for childhood pneumonia in India.
Bacterial Meningitis
Pneumococcal meningitis — 20–30% fatality rate, 30–50% survivors with permanent disabilities. Serotypes 1, 6B, 14, 23F covered by Synflorix are major meningitis-causing strains.
Septicaemia / Bacteraemia
Invasive pneumococcal bloodstream infection — high mortality in young infants. Serotypes 1, 4, 14, 18C, 19F are common causes of invasive disease — all covered by Synflorix.
Acute Otitis Media & Sinusitis
Pneumococcus and non-typeable H. influenzae (NTHi) together cause most bacterial ear infections in children. Synflorix's Protein D carrier uniquely targets NTHi too, giving broader otitis media protection than other PCVs.
👂 Otitis Media Advantage: Because most Synflorix serotypes use Protein D (an NTHi-derived carrier) instead of CRM197, clinical studies have shown Synflorix reduces acute otitis media episodes caused by non-typeable H. influenzae — a benefit CRM197-conjugated PCVs do not offer.
👥 Who Should Get Synflorix
All Infants from 6 Weeks ⭐
Primary target: all infants from 6 weeks of age up to 5 years. PCV vaccination is IAP 2024 recommended routine infant immunisation. Synflorix is licensed specifically for this paediatric age group.
Premature & Low-Birth-Weight Infants
Premature and low-birth-weight babies are at higher risk of invasive pneumococcal disease and benefit strongly from timely PCV vaccination starting at 6 weeks.
Immunocompromised Children
HIV-positive, asplenic, on chemotherapy or immunosuppressants — at high risk for IPD from any serotype. Synflorix is inactivated — safe for all these groups.
Children Prone to Ear Infections
Children with a history of recurrent otitis media may particularly benefit from Synflorix's Protein D carrier, which targets NTHi — a common cause of ear infections beyond pneumococcus.
Daycare & Preschool Attendees
Children in daycare or preschool settings have higher exposure to pneumococcal carriage and transmission — timely PCV vaccination reduces risk of disease and spread.
🔬 Synflorix Composition – Per 0.5 mL Dose
As per GSK manufacturer label. Each 0.5 mL dose (single-dose vial) contains:
| Component | Quantity | Notes |
|---|---|---|
| PROTEIN D CONJUGATED SEROTYPES (Standard Dose) | ||
| Pneumococcal Polysaccharide serotypes 1, 5, 6B, 7F, 9V, 14, 23F | 1 µg each | 7 serotypes conjugated to Protein D carrier |
| PROTEIN D CONJUGATED SEROTYPE (Higher Dose) | ||
| Pneumococcal Polysaccharide serotype 4 | 3 µg | Conjugated to Protein D carrier — higher antigen dose |
| TETANUS TOXOID CONJUGATED SEROTYPE | ||
| Pneumococcal Polysaccharide serotype 18C | 3 µg | Conjugated to Tetanus Toxoid (TT) carrier protein |
| DIPHTHERIA TOXOID CONJUGATED SEROTYPE | ||
| Pneumococcal Polysaccharide serotype 19F | 3 µg | Conjugated to Diphtheria Toxoid (DT) carrier protein |
| CARRIER PROTEINS AND ADJUVANT | ||
| Protein D carrier (from non-typeable H. influenzae) | 9 to 16 µg | Unique carrier — adds otitis media (NTHi) protection |
| Tetanus Toxoid carrier protein | 5 to 10 µg | Carries serotype 18C |
| Diphtheria Toxoid carrier protein | 3 to 6 µg | Carries serotype 19F |
| Aluminium (as Aluminium Phosphate) | 0.5 mg Al+++ | Adjuvant — enhances and prolongs immune response |
💡 Protein D — Unique to Synflorix: Unlike CRM197-based PCVs (Prevenar 13, Pneumosil, PneuBevax 14), Synflorix conjugates 8 of its 10 serotypes to Protein D, an antigen from non-typeable Haemophilus influenzae (NTHi). This generates T-cell-dependent immunity against pneumococcus AND additional protection against NTHi-related acute otitis media.
⚠️ Store between 2°C to 8°C. Do not freeze. Shake well before use. Synflorix is a ready-to-use liquid suspension in a single-dose vial — no reconstitution required. VacciHub nurses follow all storage and administration protocols.
📅 Synflorix – IAP 2024 Vaccination Schedule
| Schedule | Dose | Age | Notes |
|---|---|---|---|
| 3+1 SCHEDULE (Standard) | |||
| 3+1 | Dose 1 | 6 weeks | Earliest recommended age |
| Dose 2 | 10 weeks | Minimum 4 weeks from Dose 1 | |
| Dose 3 | 14 weeks | Minimum 4 weeks from Dose 2 | |
| Booster | 12–15 months | ⭐ Critical — restores waning immunity | |
| 2+1 SCHEDULE (Alternative) | |||
| 2+1 | Dose 1 | 2 months | Min 8 weeks between doses |
| Dose 2 | 4 months | 2 months after Dose 1 | |
| Booster | 12 months | ⭐ Min 6 months after Dose 2 | |
ℹ️ Catch-up vaccination: Children who missed the primary PCV series can receive catch-up doses of Synflorix up to 5 years of age. Schedule depends on current age. Call VacciHub for a personalised catch-up plan.
⚠️ The booster at 12–15 months is critical — antibody levels from the primary series wane significantly by 12 months. The booster triggers a powerful memory response. VacciHub sends WhatsApp reminders for all PCV doses.
⚙️ How Does Synflorix Work?
1
Intramuscular Injection
Synflorix is injected intramuscularly (anterolateral thigh in infants, deltoid in older children). The dose delivers 10 individual pneumococcal polysaccharide conjugates — 8 on Protein D, one on Tetanus Toxoid, one on Diphtheria Toxoid — adsorbed on aluminium phosphate adjuvant.
2
Carrier Proteins Recruit T-Helper Cells (T-Dependent Immunity)
The Protein D, Tetanus Toxoid and Diphtheria Toxoid carrier proteins activate CD4+ T-helper cells for each conjugate. This generates T-cell-dependent immune responses — creating true immunological memory, effective from 6 weeks, and an amplified booster response on subsequent doses.
3
10 Serotype-Specific IgG Antibodies Produced
The immune system generates protective IgG antibodies against all 10 pneumococcal serotypes. These antibodies bind pneumococcal bacteria, activate complement and facilitate opsonophagocytic killing, preventing invasive disease.
4
Additional Anti-Protein D Response — Otitis Media Protection
Because most serotypes are conjugated to Protein D, the immune system also mounts a response against this NTHi surface antigen, contributing to reduced acute otitis media episodes caused by non-typeable Haemophilus influenzae — beyond pneumococcal protection alone.
⚠️ Synflorix Side Effects
Synflorix has a well-established safety profile, consistent with other pneumococcal conjugate vaccines.
🟡 Common (Mild, 1–3 Days)
- 💉 Injection-site pain / tenderness
- 🔴 Redness or swelling at site
- 🌡️ Low-grade fever (<38.5°C)
- 😢 Irritability / crying (infants)
- 😴 Drowsiness / poor appetite
🔴 Rare – Seek Medical Attention
- 🤒 High fever (>39°C)
- 😢 Prolonged crying >3 hours
- ⚡ Febrile seizure (rare)
- 🚨 Anaphylaxis (extremely rare)
💡 Apply a cool cloth to the injection site. Paracetamol as per your paediatrician's advice. Our VacciHub nurses observe babies for 30 minutes post-vaccination and advise on fever management before leaving.
⚖️ Synflorix (PCV10) vs Prevenar 13 (PCV13) – Detailed Comparison
| Feature | Synflorix (PCV10) | Prevenar 13 (PCV13) |
|---|---|---|
| Marketed by | GSK (imported) | Pfizer (imported) |
| Manufactured by | GSK Biologicals, Belgium | Pfizer, Belgium |
| Serotypes covered | 10 | ✓ 13 |
| Carrier protein | ✓ Protein D / TT / DT | CRM197 only |
| Otitis media (NTHi) protection | ✓ Yes – unique to Protein D carrier | ✗ Not provided |
| Serotype 3 | ✗ Not included | ✓ Included |
| Serotype 6A | ✗ Not included | ✓ Included |
| Serotype 19A | ✗ Not included | ✓ Included |
| Al-Phosphate adjuvant | 0.5 mg | 0.125 mg |
| Presentation | Ready-to-use liquid vial | Ready-to-use liquid |
| Made in India | No – imported (Belgium) | No – imported (Belgium) |
| IAP recommendation | ✓ Accepted | ✓ Standard |
✅ Key advantage of Synflorix: The Protein D carrier gives Synflorix documented extra protection against acute otitis media caused by non-typeable H. influenzae — a benefit Prevenar 13's CRM197 conjugates do not provide. Prevenar 13, in turn, covers three additional serotypes (3, 6A, 19A) not in Synflorix. Your paediatrician can help decide which best suits your child.
🚫 Precautions & Contraindications
Do NOT give Synflorix if:
- Known hypersensitivity to any component including Protein D, Tetanus Toxoid, Diphtheria Toxoid or aluminium phosphate
- Severe allergic reaction to a prior PCV dose
- Acute moderate-to-severe febrile illness — defer until recovery
Use with Caution:
- Immunosuppressed patients — immune response may be reduced; PCV still strongly recommended
- Coagulation disorders — use fine needle, firm pressure post-injection
- Do NOT mix with other vaccines in the same syringe
- IM administration only — not IV or intradermal
⚠️ Do NOT freeze. Shake well before use. Synflorix is licensed only for infants and children from 6 weeks to 5 years of age — it is not indicated for adults. VacciHub nurses verify vial batch number and expiry before every injection.
🏥 Why Book Synflorix with VacciHub?
Certified Paediatric Nurses
Trained nurses experienced in infant vaccination. Correct IM injection technique. Pre-vaccination health check and 30-minute post-vaccination observation included.
Cold Chain — Never Frozen
Synflorix must NEVER be frozen. Our validated cold boxes maintain 2–8°C throughout. Temperature verified before every dose administration.
Genuine GSK Sourcing
Sourced from authorised GSK distributors only. Batch numbers fully verified and shared on your WhatsApp vaccination record.
Home Comfort
No hospital queues, no infection-risk waiting rooms. Your baby stays calm and safe at home. Especially convenient for infants and families with multiple children.
Full Series + Booster Tracking
We track all 3 primary doses and the 12–15 month booster, sending WhatsApp reminders for each. Never miss a dose in the PCV series.
Flexible & Same-Day Slots
Morning to evening, weekends included. Multiple vaccines administered in the same visit at different sites — minimising visits.
📍 Synflorix Home Vaccination – Cities We Cover
🏛️Delhi (All Areas)
🏙️Gurgaon
🌆Noida
🏘️Ghaziabad
🏗️Faridabad
🌇Greater Noida
Call +91 92050 04114 to confirm your area — same-day slots available.
❓ Frequently Asked Questions – Synflorix
Synflorix is a 10-valent Pneumococcal Conjugate Vaccine (PCV10) marketed by GSK Pharmaceuticals and manufactured by GSK Biologicals, Belgium. It covers 10 pneumococcal serotypes and uniquely conjugates most of them to Protein D, adding protection against ear infections (otitis media) from non-typeable H. influenzae — a benefit Prevenar 13 does not offer. Prevenar 13 covers 3 additional serotypes (3, 6A, 19A).
Synflorix contains pneumococcal polysaccharide serotypes 1, 4, 5, 6B, 7F, 9V, 14, 18C, 19F and 23F. Serotypes 1, 4, 5, 6B, 7F, 9V, 14 and 23F are conjugated to Protein D; serotype 18C to Tetanus Toxoid; serotype 19F to Diphtheria Toxoid. All are adsorbed on Aluminium Phosphate (0.5 mg Al+++).
3+1 (standard): Dose 1 at 6 weeks, Dose 2 at 10 weeks, Dose 3 at 14 weeks, Booster at 12–15 months.
2+1 (alternative): Dose 1 at 2 months, Dose 2 at 4 months, Booster at 12 months.
The booster is critical — antibodies wane after the primary series and the booster restores high-level memory immunity. VacciHub tracks and reminds for all doses.
2+1 (alternative): Dose 1 at 2 months, Dose 2 at 4 months, Booster at 12 months.
The booster is critical — antibodies wane after the primary series and the booster restores high-level memory immunity. VacciHub tracks and reminds for all doses.
Synflorix is manufactured by GSK Biologicals SA, Rixensart, Belgium, and marketed in India by GlaxoSmithKline Pharmaceuticals Limited, Mumbai. It is an imported vaccine. Synflorix is a registered trademark of the GSK group of companies.
Protein D is a surface protein from non-typeable Haemophilus influenzae (NTHi), used as the carrier protein for most Synflorix serotypes instead of the CRM197 used in other PCVs. Besides carrying the pneumococcal antigens, Protein D itself triggers an immune response against NTHi — a common cause of ear infections — giving Synflorix documented extra protection against acute otitis media beyond pneumococcal disease alone.
Yes. VacciHub provides home vaccination with genuine Synflorix across Delhi, Gurgaon, Noida, Ghaziabad and Faridabad and Greater Noida. Our certified nurses shake the vial well, verify batch and expiry, and follow post-vaccination monitoring. Call +91 92050 04114 or WhatsApp to book.