Rx
🏭 Bharat Biotech
❄️ Cold Chain
🌐 WHO Prequalified
🇮🇳 Made in India
Typbar TCV® · Bharat Biotech · 0.5 mL PFS · Intramuscular Use Only
Composition · MRP ₹2,353.45 incl. all taxes · Bharat Biotech label verified by VacciHub
🦠 What is Typhoid & Why Vaccinate?
Typhoid Fever
A systemic bacterial infection caused by Salmonella typhi. Spreads through contaminated food and water. Causes high prolonged fever, headache, abdominal pain, diarrhoea or constipation, rose spots. Can be fatal if untreated.
India's Burden
India accounts for an estimated 4–6 million typhoid cases per year — one of the highest globally. Children aged 2–15 are most at risk. Urban slums, travel to rural areas and poor sanitation increase risk dramatically.
Antibiotic Resistance (XDR)
Extensively Drug-Resistant (XDR) typhoid strains resistant to ampicillin, chloramphenicol, cotrimoxazole, fluoroquinolones and third-generation cephalosporins are emerging — making vaccination the most reliable prevention strategy.
Why TCV is Superior
Conjugate vaccines generate T-cell memory — providing longer-lasting protection from 6 months of age. WHO recommends TCV over older polysaccharide vaccines for all endemic countries as the preferred typhoid immunisation strategy.
👥 Who Should Get Typbar TCV?
Infants (6 Months+)
Typbar TCV can be given from 6 months of age — a major advantage over older typhoid vaccines. IAP recommends at 9–12 months as part of the extended immunisation schedule.
Children (1–15 Years)
Children are the highest-risk group for typhoid in India. TCV provides superior, longer-lasting protection vs older vaccines. Booster at 2 years if given before age 2.
International Travellers
Travel to South Asia, Southeast Asia, Sub-Saharan Africa or any typhoid-endemic region. Essential pre-travel vaccination — especially for travellers to areas with poor sanitation.
Adults in High-Risk Areas
Adults in Delhi NCR, Ghaziabad, Noida and other high-density urban areas with contaminated water supply risk. Food handlers, healthcare workers and sanitation workers.
Lab & Healthcare Workers
Persons working with Salmonella typhi in research or diagnostic labs. Typhoid vaccination is an occupational health requirement in microbiology facilities.
Immunocompromised Patients
HIV-positive individuals, transplant recipients and others on immunosuppressive therapy have higher typhoid risk. Consult your doctor — TCV may be given with appropriate caution.
🔬 Typbar TCV Composition – Per 0.5 mL Dose
As per Bharat Biotech manufacturer label. Each 0.5 mL prefilled syringe contains:
| Component | Quantity | Notes |
|---|---|---|
| ACTIVE INGREDIENT | ||
| Purified Vi Capsular Polysaccharide of Salmonella typhi Ty2 | 25 µg | Conjugated to Tetanus Toxoid (T-cell-dependent response) |
| CARRIER PROTEIN (Conjugate) | ||
| Tetanus Toxoid | 25 µg | Carrier protein enabling T-cell memory. Same toxoid used in DTP vaccines. |
| EXCIPIENTS | ||
| Sodium Chloride IP | 4.5 mg | Tonicity agent |
| Water for Injections IP | q.s. to 0.5 mL | Vehicle |
💡 No Aluminium. No Preservatives. Typbar TCV contains no aluminium adjuvant, no thimerosal and no other preservatives — making it one of the cleanest vaccine formulations available. The Tetanus Toxoid carrier protein itself drives the T-cell response without needing additional adjuvants.
⚠️ Storage: Store at +2°C to +8°C. Do NOT freeze. Discard if frozen. Shake well before use. Our VacciHub nurses maintain strict cold chain — vaccines never leave the validated cold box until the moment of administration.
📅 IAP 2024 – Typbar TCV Vaccination Schedule
| Group | Dose | Age / Timing | Notes |
|---|---|---|---|
| Infants (routine) | 1 Dose | 9–12 months | IAP extended schedule; given alongside MMR/MR |
| Booster (if given <2 yrs) | Booster | 2 years of age | Booster recommended if primary dose was given before 2nd birthday |
| Children 2–15 years (catch-up) | 1 Dose | Any time | Single dose catch-up; repeat every 3 years in high-risk areas |
| Adults | 1 Dose | Any time | Repeat every 3 years if continued risk (travel, occupation) |
| Pre-travel | 1 Dose | ≥2 weeks before travel | Travel to endemic regions; South Asia, Africa, Southeast Asia |
ℹ️ Minimum age: Typbar TCV is approved from 6 months. IAP recommends first dose at 9–12 months for routine vaccination. It replaces older typhoid vaccines (Vi polysaccharide / Typbar) which were only effective from 2 years.
⚙️ How Does Typbar TCV Work?
1
Vi-Tetanus Toxoid Conjugate Injected
The 0.5 mL prefilled syringe delivers purified Vi capsular polysaccharide (25 µg) covalently conjugated to Tetanus Toxoid (25 µg). Administered intramuscularly — deltoid in older children/adults, anterolateral thigh in infants.
2
T-Cell Activation via Tetanus Toxoid Carrier
The Tetanus Toxoid carrier recruits T-helper cells (CD4+), converting the immune response from T-independent (as in plain polysaccharide vaccines) to T-dependent. This is the critical conjugate advantage — without T-cell help, no immunological memory is created.
3
Anti-Vi IgG Antibodies + Memory Cells Generated
The immune system generates high-titre IgG antibodies against the Vi capsular polysaccharide of S. typhi. These antibodies coat the bacteria and facilitate opsonophagocytosis. Memory B and T-cells enable rapid response on re-exposure.
4
Protection From 6 Months — Lasting Years
Protection develops within 2 weeks. Clinical trials show efficacy of 81.6% against typhoid. Immunity lasts significantly longer than plain polysaccharide vaccines — recommended repeat every 3 years in high-risk settings rather than the 3-yearly requirement for older vaccines.
✅ Clinical evidence: Typbar TCV demonstrated 81.6% vaccine efficacy in a Phase 3 controlled human infection study — the highest efficacy ever demonstrated for a typhoid vaccine in a challenge model. Published in The Lancet (2017).
⚠️ Typbar TCV Side Effects
Typbar TCV has an excellent safety profile established across large clinical trials and millions of real-world doses in national programmes.
🟡 Common (Mild, Transient)
- 💉 Injection-site pain / tenderness
- 🔴 Redness or swelling at site
- 🌡️ Low-grade fever (<38.5°C)
- 😢 Irritability (in infants)
- 😴 Mild drowsiness / fatigue
🔴 Rare – Seek Medical Attention
- 🤒 High fever (>39°C)
- 😢 Prolonged crying in infants (>3 hrs)
- 💪 Extensive limb swelling
- 🚨 Anaphylaxis (extremely rare)
💡 Post-vaccination: Apply a clean cool cloth (not ice) to the injection site. Paracetamol may be given as per your doctor's advice for fever or pain. Observe the child for 30 minutes post-vaccination. Our VacciHub nurses wait and monitor before leaving.
⚖️ Typbar TCV vs Older Typhoid Vaccines
| Feature | Typbar TCV (Conjugate) | Typbar / Typhim Vi (Polysaccharide) | Oral Ty21a |
|---|---|---|---|
| Vaccine Type | ✓ Conjugate (T-cell dependent) | Polysaccharide (T-independent) | Live attenuated oral |
| Min Age | ✓ 6 months | 2 years | 6 years |
| Immunological Memory | ✓ Yes — long-lasting | No — wanes in 3 years | Limited |
| Efficacy | ✓ ~81.6% (challenge model) | ~55–75% | ~50–67% |
| Doses Required | ✓ 1 dose | 1 dose | 4 capsules over 7 days |
| WHO Prequalified | ✓ Yes (2017 — world's first) | Yes | Yes |
| Protects infants <2 yrs | ✓ Yes | No | No |
| Made in India | ✓ Bharat Biotech, Hyderabad | Sanofi / various | Various |
| MRP (approx) | ₹2,353.45 | Lower | Lower |
🚫 Precautions & Contraindications
Do NOT give Typbar TCV if:
- Known hypersensitivity to any vaccine component including Tetanus Toxoid
- Severe allergic reaction to a prior Typbar TCV or TCV dose
- Acute moderate-to-severe febrile illness on vaccination day — defer until recovery
Use with Caution:
- Immunosuppressed individuals — immune response may be reduced; still recommended
- Pregnancy — limited data; benefit generally outweighs risk, especially for travel; consult doctor
- If a Tetanus Toxoid-containing vaccine was given recently — discuss timing with doctor
- Thrombocytopenia or coagulation disorders — injection site bleeding risk
⚠️ Do NOT freeze. Freezing destroys the vaccine's efficacy. Always verify the VVM (Vaccine Vial Monitor) indicator before use. VacciHub nurses carry vaccines in validated cold boxes and check VVM status before every administration.
🏥 Why Book Typbar TCV with VacciHub?
Certified Nursing Staff
Trained, certified nurses with paediatric and adult vaccination experience. Proper IM technique and post-vaccination monitoring guaranteed.
Cold Chain — Never Frozen
Typbar TCV must NEVER be frozen. Our validated cold boxes maintain exactly 2–8°C. Potency guaranteed from warehouse to your home.
100% Genuine Bharat Biotech
Sourced from authorised Bharat Biotech distributors only. Batch numbers (B.No.) traceable. Full transparency on MFG and EXP dates.
No Hospital Visits
Skip queues, avoid hospital-acquired infections. Your nurse comes to you — especially convenient for infants, toddlers and busy families.
Digital Vaccination Record
Complete vaccination history maintained. WhatsApp post-visit report with batch number, expiry and booster reminder shared after every dose.
Same-Day & Weekend Slots
Pre-travel vaccination at short notice? We offer same-day bookings across Delhi NCR, including Saturdays and Sundays.
📍 Typbar TCV Home Vaccination – Cities We Cover
🏛️Delhi (All Areas)
🏙️Gurgaon
🌆Noida
🏘️Ghaziabad
🏗️Faridabad
🌇Greater Noida
Not sure about your area? Call +91 92050 04114 — same-day slots available.
❓ Frequently Asked Questions – Typbar TCV
Typbar TCV is a Typhoid Vi Conjugate Vaccine by Bharat Biotech — the world's first WHO-prequalified typhoid conjugate vaccine. It works by conjugating the Vi polysaccharide of Salmonella typhi to Tetanus Toxoid, creating a T-cell-dependent immune response with true immunological memory. Unlike older polysaccharide vaccines (e.g. Typbar/Typhim Vi), it is effective from 6 months of age, generates longer-lasting protection and provides a booster effect on subsequent exposure.
The Maximum Retail Price (MRP) of Typbar TCV is ₹2,353.45 inclusive of all taxes as printed on the manufacturer label (Bharat Biotech). Call VacciHub at +91 92050 04114 for home vaccination pricing inclusive of nurse visit and cold chain delivery.
Typbar TCV can be given from 6 months of age. IAP 2024 recommends the first dose at 9–12 months as part of the extended immunisation schedule. A booster is recommended at 2 years if the primary dose was given before the 2nd birthday. Older children and adults can receive it at any time as a catch-up or travel vaccine.
Yes. Typbar TCV was prequalified by the World Health Organization (WHO) in 2017 — making it the world's first typhoid conjugate vaccine to receive WHO prequalification. This enables its use in GAVI-supported national immunisation programmes. It has been recommended by WHO's Strategic Advisory Group of Experts (SAGE) for use in typhoid-endemic countries.
Absolutely. VacciHub provides home vaccination with genuine Bharat Biotech Typbar TCV across Delhi, Gurgaon, Noida, Ghaziabad, Faridabad and Greater Noida. Our nurses maintain strict cold chain (2–8°C, never frozen) throughout. Call +91 92050 04114 or WhatsApp to book.
After the primary dose at 9–12 months and booster at 2 years, subsequent doses are recommended every 3 years for persons in high-risk areas or with occupational/travel exposure. For one-time travellers to endemic regions, a single dose before travel provides adequate short-term protection.
Common side effects are mild: injection-site pain, redness, swelling, low-grade fever and irritability in infants — all resolving within 1–3 days. Typbar TCV has no aluminium adjuvant and no preservatives, contributing to its excellent tolerability. Serious adverse events are extremely rare. Observe the recipient for 30 minutes post-vaccination — our VacciHub nurses follow this protocol.