Rx
🏭 GlaxoSmithKline (GSK)
❄️ Cold Chain
⭐ 6-in-1 Combination
🌍 Imported – GSK Global
🦠 Acellular Pertussis
Infanrix Hexa® · GlaxoSmithKline · Syringe + Vial, Mix Before Use · Intramuscular Use
Full composition per 0.5 mL · Al(OH)₃ 0.5mg + AlPO₄ 0.32mg adjuvants · No preservative · Store 2–8°C · Not to be Frozen · Mix Before Use
🛡️ 6 Diseases Infanrix Hexa Protects Against
1
Diphtheria
Bacterial throat membrane infection — can block airways and cause heart failure. Fatal in unvaccinated children.
2
Tetanus
Lockjaw — Clostridium tetani toxin causing severe muscle spasms. No cure; prevention only through vaccination.
3
Pertussis (Whooping Cough)
Highly contagious — violent coughing fits. Deadly for infants under 6 months. Acellular pertussis formula is highly effective.
4
Hepatitis B
Viral liver infection causing chronic liver disease and liver cancer. HBsAg (rDNA) 10 mcg provides strong protection.
5
Poliomyelitis (IPV)
All 3 Salk strains on Vero cells — Types 1, 2 & 3. Inactivated polio vaccine delivers injectable protection alongside oral polio drops.
6
Hib (H. influenzae b)
Leading cause of bacterial meningitis and pneumonia in infants. Hib-PRP 10 mcg conjugated to Tetanus Toxoid provides T-cell dependent immunity.
💡 Why 6-in-1? Combining 6 vaccines into one injection means fewer total injections for the baby, fewer clinic/home visits, better compliance with the full immunisation schedule, and reduced anxiety for both baby and parents — while providing identical protection to 6 separate vaccines.
👥 Who Should Get Infanrix Hexa?
All Infants from 6 Weeks ⭐
Primary target: all healthy infants starting from 6 weeks of age. IAP 2024 includes 6-in-1 (DTaP-HepB-IPV-Hib) as part of the extended immunisation schedule.
Premature Babies
Preterm infants are highly vulnerable to Hib meningitis, pertussis and hepatitis B. Infanrix Hexa is given at chronological age (6 weeks), not corrected gestational age.
Infants with Chronic Conditions
Congenital heart disease, chronic lung conditions, liver disease — these increase the severity of Hib infections and pertussis. 6-in-1 vaccination is critical for protection.
Immunocompromised Infants
HIV-exposed or HIV-positive infants, those with primary immunodeficiencies (consult doctor). Infanrix Hexa is an inactivated vaccine — no live components, safe for immunocompromised.
Catch-Up Vaccination
Infants who missed early doses can receive catch-up vaccination. The schedule depends on age at first dose — call VacciHub for a personalised catch-up plan.
Families Preferring Low-Reactogenicity Vaccine
Parents who prefer an acellular pertussis (DTaP) formulation – clinically shown to cause fewer fevers and injection-site reactions than whole-cell (DTwP) vaccines, from a leading global manufacturer (GSK).
🔬 Infanrix Hexa Composition – Per 0.5 mL Reconstituted Dose
As per GlaxoSmithKline manufacturer label. Supplied as a pre-filled syringe (DTaP-HepB-IPV suspension) + a vial (lyophilised Hib powder), mixed just before injection. After reconstitution, each 0.5 mL dose contains:
| Component | Quantity | Notes |
|---|---|---|
| ACTIVE INGREDIENTS – 6 ANTIGENS | ||
| Diphtheria Toxoid | ≥ 30 IU | Adsorbed on Aluminium Hydroxide |
| Tetanus Toxoid | ≥ 40 IU | Adsorbed on Aluminium Hydroxide |
| B. pertussis Toxoid (PT) | 25 mcg | Acellular – purified pertussis antigen (not whole-cell) |
| Filamentous Haemagglutinin (FHA) | 25 mcg | Acellular pertussis antigen |
| Pertactin (PRN) | 8 mcg | Acellular pertussis antigen |
| HBsAg (rDNA) | 10 mcg | Recombinant Hepatitis B surface antigen, produced in yeast (S. cerevisiae) |
| INACTIVATED POLIO VACCINE (Salk strains – Vero cells) | ||
| Poliovirus Type 1 (Mahoney strain) | 40 DU | Inactivated, grown on Vero cells (Salk) |
| Poliovirus Type 2 (MEF-1 strain) | 8 DU | Inactivated, grown on Vero cells |
| Poliovirus Type 3 (Saukett strain) | 32 DU | Inactivated, grown on Vero cells |
| HIB CONJUGATE (freeze-dried powder, mixed before use) | ||
| Hib PRP (H. influenzae type b polysaccharide) | 10 mcg | Conjugated to Tetanus Toxoid (TT) carrier protein |
| Tetanus Toxoid carrier protein (Hib conjugate) | ~25 mcg | T-cell dependent immunity for Hib |
| ADJUVANTS & OTHER EXCIPIENTS | ||
| Aluminium Hydroxide, hydrated (Al(OH)₃) | 0.5 mg Al3+ | Adjuvant – adsorbs Diphtheria, Tetanus & Pertussis antigens |
| Aluminium Phosphate (AlPO₄) | 0.32 mg Al3+ | Adjuvant – adsorbs HBsAg |
| Preservative | None | Single-dose presentation – thiomersal-free |
💡 Acellular Pertussis (DTaP): Infanrix Hexa uses killed whole Bordetella pertussis bacteria — the original, highly immunogenic pertussis vaccine formula used in India for decades. DTaP generates a broader antibody response than whole-cell pertussis (DTwP) and provides strong herd protection. It may cause more local reactions (fever, injection-site soreness) than whole-cell formulas — paracetamol management is recommended.
⚠️ Storage: +2°C to +8°C. NOT TO BE FROZEN. SHAKE WELL BEFORE USE. VacciHub nurses verify cold chain compliance and shake the syringe before every administration.
📅 Infanrix Hexa – IAP 2024 Immunisation Schedule
| Dose | Age | Vaccine | Notes |
|---|---|---|---|
| HEPATITIS B – BIRTH DOSE (Given Separately) | |||
| HepB Birth | At birth (within 24 hrs) | HepB monovalent (separate) | Birth dose MUST be given before starting 6-in-1 series |
| INFANRIX HEXA PRIMARY SERIES (3 DOSES) | |||
| Dose 1 | 6 Weeks | Infanrix Hexa (0.5 mL IM) | Anterolateral thigh · First 6-in-1 dose |
| Dose 2 | 10 Weeks | Infanrix Hexa (0.5 mL IM) | Minimum 4 weeks from Dose 1 |
| Dose 3 | 14 Weeks | Infanrix Hexa (0.5 mL IM) | Minimum 4 weeks from Dose 2 |
| BOOSTERS (Given as Separate Vaccines) | |||
| DTaP Booster | 15–18 Months | DTaP (not 6-in-1) or DTwP | DTP component booster only — Hib & HepB series complete |
| DT Booster 2 | 4–6 Years | DT / Tdap (pre-school) | School-entry DTP booster |
ℹ️ HepB birth dose is separate: The Hepatitis B birth dose (within 24 hours of birth) is critical and given as a monovalent HepB vaccine — not as part of the 6-in-1 series. After 3 doses of Infanrix Hexa, the HepB primary series (total 4 doses: birth + 3 Infanrix Hexa) is complete. No separate HepB booster needed.
⚠️ Booster vaccine: The 15–18 month booster is given as a separate DTaP or DTwP — not as another Infanrix Hexa dose. This is because Hib and HepB series are complete after 3 primary doses. Your paediatrician will prescribe the appropriate booster vaccine.
⚙️ How Does Infanrix Hexa Work?
1
6 Antigens Delivered in One IM Injection
After shaking well, 0.5 mL is injected into the anterolateral thigh (infants). The single injection delivers Diphtheria Toxoid, Tetanus Toxoid, acellular B. pertussis antigens (PT, FHA, Pertactin), HBsAg rDNA (10mcg), IPV (all 3 poliovirus strains on Vero cells), and Hib-PRP conjugated to Tetanus Toxoid.
2
Aluminium Adjuvant Depot Effect
Diphtheria, Tetanus and Pertussis antigens are adsorbed on Aluminium Hydroxide (0.5 mg Al3+), while HBsAg is adsorbed on Aluminium Phosphate (0.32 mg Al3+). This creates a depot at the injection site — slowing antigen release and providing prolonged stimulation of antigen-presenting cells, dendritic cells and macrophages for stronger immune responses.
3
6 Independent Antibody Responses Generated
The immune system generates specific antibodies against each of the 6 antigens simultaneously: anti-Diphtheria toxoid IgG, anti-Tetanus toxoid IgG, anti-Pertussis antibodies, anti-HBs IgG, anti-poliovirus neutralising antibodies (all 3 types), and anti-PRP IgG (Hib). Memory cells for all 6 are formed.
4
Boosted After Each Dose — Mature After 3 Doses
Each dose amplifies antibody titres. After the 3-dose primary series (6–14 weeks), protective levels are achieved for all 6 diseases. The DTP booster at 15–18 months restores waning DTP immunity and consolidates long-term protection.
⚠️ Infanrix Hexa Side Effects
Infanrix Hexa uses acellular pertussis (DTaP) — generally causing fewer and milder local and systemic reactions than whole-cell pertussis (DTwP) vaccines. Mild reactions can still occur and are expected as the vaccine builds immunity.
🟡 Common (Expected with DTaP)
- 💉 Injection-site pain, redness, swelling
- 🌡️ Fever (common — may be moderate)
- 😢 Irritability / prolonged crying
- 😴 Drowsiness / poor feeding
- 🔴 Local swelling / induration at site
🔴 Rare – Seek Medical Attention
- 🤒 High fever (>39.5°C)
- 😢 Persistent crying >3 hours
- 😵 Hypotonic-hyporesponsive episode
- ⚡ Febrile seizure (rare)
- 🚨 Anaphylaxis (extremely rare)
💡 Managing DTaP reactions: Pre-emptive or post-vaccination Paracetamol (10–15 mg/kg) may be given for fever and pain as per your paediatrician's advice. Apply a cool cloth (not ice) to injection site. These reactions are generally self-limiting within 48–72 hours. Our VacciHub nurses observe babies for 30 minutes and advise parents on fever management before leaving.
⚖️ Infanrix Hexa (DTaP 6-in-1) vs Hexasiil PFS (DTwP 6-in-1)
| Feature | Infanrix Hexa (GSK) | Hexasiil PFS (SII) |
|---|---|---|
| Manufacturer | ✓ GSK – global vaccine leader | SII (India) |
| Made in India | No – imported (Belgium) | ✓ Yes – Pune |
| Pertussis type | ✓ Acellular (DTaP) – purified antigens | Whole-cell (DTwP) |
| Pertussis antigens | ✓ 3 purified antigens (PT, FHA, Pertactin) | Whole killed bacteria – ≥ 4 IU |
| Fever risk post-dose | ✓ Lower (acellular – less reactogenic) | Higher (whole-cell – common, self-limiting) |
| Local reactions | ✓ Fewer | More frequent |
| Hib carrier protein | Tetanus Toxoid (TT) | Tetanus Toxoid (TT) – same approach |
| HBsAg content | 10 mcg | ✓ 15 mcg |
| Presentation | 2-component (PFS + vial, mix before use) | ✓ Single ready-to-use PFS |
| Price | Higher (imported, premium) | ✓ More affordable |
| IAP recommended | ✓ Yes (preferred aP option) | ✓ Yes (accepted) |
| Overall immunogenicity | ✓ Excellent (aP well tolerated) | ✓ Strong (wP highly immunogenic) |
ℹ️ Which to choose? Infanrix Hexa (DTaP 6-in-1) is effective, affordable and Made in India — excellent for families prioritising cost or availability. Hexasiil PFS (DTwP 6-in-1) has fewer fever and local reactions — preferred when tolerability is the priority. Both provide equivalent protection against all 6 diseases. Your paediatrician can advise based on your baby's specific health situation.
🚫 Precautions & Contraindications
Do NOT give Infanrix Hexa if:
- Encephalopathy within 7 days of a prior pertussis-containing vaccine
- Anaphylaxis to a prior Infanrix Hexa dose or any component
- Acute moderate-to-severe febrile illness — defer until recovery
- Progressive neurological disorder or unstable epilepsy
Use with Caution — Discuss with Paediatrician:
- History of febrile seizures or family history of seizures
- Previous hypotonic-hyporesponsive episode after DTP
- Persistent high-pitched crying >3 hours after prior dose
- Thrombocytopenia or coagulation disorders
- Immunosuppressed infants — still recommended; immune response may be reduced
⚠️ NOT TO BE FROZEN. SHAKE WELL BEFORE USE. Do NOT inject intradermally or intravenously — intramuscular only (anterolateral thigh in infants). Do NOT mix with other vaccines in the same syringe. VacciHub nurses follow all these protocols at every home visit.
🏥 Why Book Infanrix Hexa with VacciHub?
Certified Paediatric Nurses
Trained nurses experienced in infant vaccination. Correct anterolateral thigh IM injection. Pre-vaccination health check and 30-minute post-vaccination observation.
Cold Chain — Never Frozen
Infanrix Hexa must NEVER be frozen. Our validated cold boxes maintain exactly 2–8°C. Temperature verified before every administration.
100% Genuine GSK Infanrix Hexa
Sourced from authorised GSK distributors. Batch numbers and expiry dates fully transparent on WhatsApp vaccination record.
Home Comfort for Infants
Babies are calmer at home. No hospital queues, no waiting room infections. Our nurse comes to you — the safest environment for your newborn.
Full 3-Dose Series Tracking
We track all 3 doses at 6, 10, 14 weeks and send WhatsApp reminders for each. Also remind for the 15-18 month DTP booster.
Flexible & Same-Day Slots
Morning to evening, weekends included. Multiple vaccines can be given in the same visit (at different sites) to minimise visits.
📍 Infanrix Hexa Home Vaccination – Cities We Cover
🏛️Delhi (All Areas)
🏙️Gurgaon
🌆Noida
🏘️Ghaziabad
🏗️Faridabad
🌇Greater Noida
Call +91 92050 04114 to confirm your area — same-day slots available.
❓ Frequently Asked Questions – Infanrix Hexa
Infanrix Hexa is a 6-in-1 combination vaccine by GlaxoSmithKline (GSK). Each 0.5 mL reconstituted dose protects against: (1) Diphtheria (≥30 IU toxoid), (2) Tetanus (≥40 IU toxoid), (3) Pertussis/Whooping Cough (acellular – PT, FHA, Pertactin), (4) Hepatitis B (HBsAg rDNA 10 mcg), (5) Poliomyelitis (IPV – all 3 strains on Vero cells) and (6) Hib (H. influenzae type b PRP 10 mcg conjugated to TT).
Primary series: Dose 1 at 6 weeks, Dose 2 at 10 weeks, Dose 3 at 14 weeks (intramuscular, anterolateral thigh).
HepB birth dose: Must be given within 24 hours of birth as a separate monovalent HepB vaccine before starting Infanrix Hexa.
Booster: A DTaP/DTwP-containing booster at 15–18 months (not another Infanrix Hexa dose — Hib and HepB series are complete after 3 primary doses).
HepB birth dose: Must be given within 24 hours of birth as a separate monovalent HepB vaccine before starting Infanrix Hexa.
Booster: A DTaP/DTwP-containing booster at 15–18 months (not another Infanrix Hexa dose — Hib and HepB series are complete after 3 primary doses).
Both are 6-in-1 vaccines covering the same 6 diseases. Key differences: Infanrix Hexa (GSK) uses acellular pertussis (DTaP) — generally fewer fevers and local reactions, but imported and costs more. Hexasiil PFS (SII) uses whole-cell pertussis (DTwP) — more reactogenic but made in India and more affordable. Infanrix Hexa is a 2-component pack (syringe + vial, mixed before use) while Hexasiil PFS is a single ready-to-use syringe. Both are IAP-accepted. Your paediatrician can advise based on your child's health and family preference.
Yes. VacciHub provides home vaccination with genuine GSK Infanrix Hexa across Delhi, Gurgaon, Noida, Ghaziabad, Faridabad and Greater Noida. Our certified nurses reconstitute the vaccine correctly (mixing the syringe suspension with the Hib powder vial), administer the correct IM injection, follow post-vaccination monitoring and track your 3-dose series with reminders. Call +91 92050 04114 or WhatsApp to book.
Because Infanrix Hexa uses acellular pertussis, it commonly causes injection-site pain, redness or swelling, mild-to-moderate fever, irritability and drowsiness — generally less frequent than whole-cell (DTwP) vaccines. These reactions are self-limiting (24–48 hours). Paracetamol (10–15 mg/kg) may be given for fever/pain as per your paediatrician's advice. Serious adverse events (persistent crying, febrile seizure, anaphylaxis) are rare. Our VacciHub nurses observe babies for 30 minutes post-vaccination and advise parents on management.
Yes — absolutely critical. The Hepatitis B birth dose must be given within 24 hours of birth as a separate monovalent HepB vaccine. This protects against perinatal (mother-to-child) transmission, the most common route of HepB infection in India. After the HepB birth dose, the subsequent 3 doses of HepB come through the Infanrix Hexa series at 6, 10, 14 weeks — completing the total 4-dose HepB schedule.
Infanrix Hexa is supplied as two components: a pre-filled syringe containing the DTaP-HepB-IPV suspension, and a vial containing freeze-dried (lyophilised) Hib powder. Just before injection, the entire contents of the syringe are added to the vial and shaken until the powder is fully dissolved, forming the complete 6-in-1 dose. Using the vaccine without properly reconstituting and shaking it could result in an incomplete or incorrect dose. VacciHub nurses always reconstitute and mix the vaccine correctly immediately before administration.