Rx
🏭 Bharat Biotech
❄️ Cold Chain
🧬 rDNA – No Live Virus
🇮🇳 Made in India
👶 Paediatric 0.5 mL
⚠️ Schedule H
REVAC-B PAED® · Bharat Biotech · 0.5 mL Single Dose Vial · Intramuscular Injection
Composition · Batch & Storage Details · See product insert for full prescribing information
ℹ️
PAED vs Adult dose: REVAC-B PAED (0.5 mL, for ages 0–19 years) is a different presentation from Bharat Biotech's adult 1 mL Revac-B+ (20 years and above). If you need the adult 1 mL dose, please see our Revac-B+ Adult Hepatitis B Vaccine page. Always follow your doctor's prescribed dose – VacciHub nurses administer strictly as prescribed.
🦠 About Hepatitis B – Why Vaccinate Early?
Lifelong Liver Disease Risk
Hepatitis B virus (HBV) can cause chronic liver disease, cirrhosis and liver cancer. India carries one of the world's largest chronic HBV burdens, with tens of millions of chronic carriers.
Mother-to-Child Spread is #1 Route
In India, the most common way infants acquire HBV is transmission from an infected mother at birth. Without prompt vaccination, up to 90% of infected newborns go on to develop chronic infection.
Excellent, Long-Lasting Protection
A completed vaccine series produces protective antibodies in roughly 95% of recipients, and the Hepatitis B vaccine remains the only licensed vaccine proven to help prevent a form of liver cancer.
Why the rDNA Approach?
REVAC-B PAED uses recombinant DNA technology: HBsAg is expressed in yeast cells, purified, and formulated without any live virus, giving a consistent, well-tolerated antigen source.
👥 Who Should Get REVAC-B PAED?
All Newborns – Birth Dose ⭐
The single most important dose. IAP guidance calls for the first Hepatitis B dose within 24 hours of birth for every newborn, to block mother-to-child transmission.
Infants – Primary Series
Doses 2, 3 and 4 are usually given as part of a 6-in-1 combination vaccine at 6, 10 and 14 weeks, continuing protection built by the birth dose.
Unvaccinated Children – Catch-Up
Children under 20 who missed their birth dose or infant series can start a 3-dose catch-up schedule (0, 1, 6 months) at any time.
Young Travellers
Children travelling to Hepatitis B endemic regions in Southeast Asia or Sub-Saharan Africa should complete their series before travel; accelerated schedules are available if time is short.
Household Contacts
Children living with an HBsAg-positive family member are at ongoing risk and should be fully vaccinated, with an anti-HBs titre check where advised by the paediatrician.
Need the Adult Dose Instead?
Adults 20 years and above should receive the 1 mL Revac-B+ presentation rather than REVAC-B PAED – see our Revac-B+ Adult page.
🔬 REVAC-B PAED Composition – Per 0.5 mL Paediatric Dose
As per Bharat Biotech manufacturer labelling for the paediatric presentation. Always refer to the product insert in the pack for exact per-batch quantities.
| Component | Approx. Quantity | Role |
|---|---|---|
| Active Ingredient | ||
| Purified HBsAg (Hepatitis B Surface Antigen) | ≥ 10 µg | Recombinant antigen produced in yeast (rDNA). Triggers protective anti-HBs antibody response. No live virus. |
| Adjuvant | ||
| Aluminium Hydroxide gel | Proportional to 0.5 mL dose | Creates a depot at the injection site, prolonging antigen exposure and boosting the immune response. |
| Preservative | ||
| Thiomersal I.P. | Trace amount (multi-dose vial standard) | Ethylmercury-based preservative. Cleared from the body quickly; considered safe at vaccine doses by WHO and DCGI. |
| Dosage Form | ||
| Form | Suspension for IM injection | Shake well – the adjuvant settles on standing. |
| Route | Intramuscular only | Anterolateral thigh (infants) · Deltoid (older children) |
| Storage | 2°C to 8°C | DO NOT FREEZE · Shake well before use |
💡 Thiomersal – is it safe for babies? Thiomersal contains ethylmercury, not methylmercury. Ethylmercury clears from the body quickly and does not build up in tissue the way methylmercury does. WHO, DCGI and major health bodies consider thiomersal-containing vaccines safe, including for newborns and infants, at the doses used.
⚠️ DO NOT FREEZE. Shake well before use. Freezing damages the aluminium adjuvant and reduces effectiveness – VacciHub nurses check every vial for freeze indicators before administering.
📅 Hepatitis B Vaccination Schedule with REVAC-B PAED (IAP 2024)
| Dose | Age / Timing | Vaccine | Notes |
|---|---|---|---|
| Infant Primary Series (4 Doses Total) | |||
| Birth Dose | Within 24 hours of birth | REVAC-B PAED (0.5 mL) monovalent | Most critical dose – blocks mother-to-child transmission |
| Dose 2 | 6 weeks | As part of 6-in-1 combination | HepB component of hexavalent vaccine |
| Dose 3 | 10 weeks | As part of 6-in-1 combination | HepB component of hexavalent vaccine |
| Dose 4 | 14 weeks | As part of 6-in-1 combination | Completes the 4-dose infant series |
| Child Catch-Up Schedule (3 Doses, Under 20 Years) | |||
| Dose 1 | Day 0 | REVAC-B PAED (0.5 mL) | Any unvaccinated child under 20 years |
| Dose 2 | 1 month after Dose 1 | REVAC-B PAED (0.5 mL) | Minimum 4 weeks after Dose 1 |
| Dose 3 | 6 months after Dose 1 | REVAC-B PAED (0.5 mL) | Completes the series |
🚨 Babies born to HBsAg-positive mothers should receive the Hepatitis B vaccine and Hepatitis B Immunoglobulin (HBIG) within 12 hours of birth, at separate injection sites, for maximum protection. Call us immediately after delivery for an urgent home visit.
⚙️ How Does REVAC-B PAED (rDNA) Work?
1
Antigen injected intramuscularly. After shaking well, the 0.5 mL dose is injected into the anterolateral thigh (infants) or deltoid (older children). The aluminium-adsorbed HBsAg forms a slow-release depot at the injection site.
2
Immune system recognises HBsAg as foreign. Antigen-presenting cells process the surface antigen and display it to T-helper cells, while the adjuvant boosts the surrounding immune signalling.
3
Protective antibodies are produced. B-cells mature into plasma cells that secrete anti-HBs antibodies, which bind and neutralise HBV particles, preventing them from infecting liver cells.
4
Long-term immune memory is established. After completing the full series, most healthy children develop lasting seroprotection (anti-HBs ≥ 10 mIU/mL), with memory cells ready to respond quickly if exposed later.
⚠️ REVAC-B PAED Side Effects
REVAC-B PAED has a well-established safety profile; Hepatitis B vaccines are among the most widely used and best-studied vaccines given to infants worldwide.
🟡 COMMON (MILD, 1–3 DAYS)
💉 Soreness or redness at injection site
🌡️ Mild, low-grade fever
😴 Fussiness or mild irritability in infants
🤕 Reduced appetite for a short time
🔴 RARE – SEEK MEDICAL ATTENTION
🚨 Anaphylaxis (extremely rare)
🔥 High fever above 39°C
⚡ Severe allergic reaction or persistent crying
💡 A cool cloth on the injection site and paracetamol (as advised by your doctor) can help with fever or discomfort. VacciHub nurses observe every child for 30 minutes after the injection before ending the home visit.
🚫 Precautions & Contraindications
Do NOT give REVAC-B PAED if:
There is a known hypersensitivity to yeast or any vaccine component (including thiomersal); there has been anaphylaxis after a previous dose of any Hepatitis B vaccine; or the child has acute severe febrile illness on the day of vaccination (defer until recovery).
Special Situations:
Preterm or low birth-weight infants: the birth dose is still recommended, though some paediatricians adjust timing based on clinical stability – follow your doctor's advice.
Immunocompromised children: may need additional doses or antibody titre checks after completing the series.
Bleeding disorders: a fine needle with firm post-injection pressure is used to reduce bruising risk.
⚠️ Intramuscular injection only – never intravenous, intradermal or subcutaneous. DO NOT FREEZE. VacciHub nurses are trained in correct paediatric injection technique for every age group.
🏥 Why Book REVAC-B PAED with VacciHub?
Birth Dose Priority
Urgent home visits within 24 hours of delivery, at your home or hospital of delivery.
Validated Cold Chain
Cold boxes maintained at 2–8°C with freeze-indicator checks before every dose.
100% Genuine Bharat Biotech
Sourced only from authorised distributors, with batch details shared on WhatsApp after every visit.
Full Series Tracking
Birth dose and all follow-up doses tracked with WhatsApp reminders so no dose is missed.
Home Convenience
No hospital queues – especially valuable for newborns and young children.
Same-Day & Urgent Slots
Priority scheduling for birth-dose requests; flexible slots for the rest of the series.
📍 REVAC-B PAED Home Vaccination – Cities We Cover
🏛️Delhi (All Areas)
🏙️Gurgaon
🌅Noida
🏠Ghaziabad
🏗️Faridabad
🌚Greater Noida
Call +91 92050 04114 anytime – urgent birth-dose requests are given priority.
❓ Frequently Asked Questions – REVAC-B PAED
REVAC-B PAED is the 0.5 mL paediatric presentation of Bharat Biotech's recombinant Hepatitis B vaccine, used for infants and children up to 19 years. Revac-B+ is the 1 mL adult presentation with double the antigen content, for those 20 years and above.
Yes. It is commonly used as the Hepatitis B birth dose. IAP guidance recommends giving it within 24 hours of birth, and VacciHub prioritises these urgent home visits across Delhi NCR.
A birth dose within 24 hours, followed by doses at 6, 10 and 14 weeks (usually as part of a 6-in-1 vaccine), completing a 4-dose primary series.
Yes. It contains ethylmercury, which clears from the body quickly, unlike methylmercury. WHO and DCGI consider thiomersal-containing vaccines safe at the doses used, including for newborns.
A 3-dose catch-up schedule (0, 1, 6 months) can be started at any age under 20 years using REVAC-B PAED.
Yes, certified nurses provide home visits across Delhi, Gurgaon, Noida, Ghaziabad, Faridabad and Greater Noida, with validated cold-chain transport for every dose.