Rx
🏭 Bharat Biotech
💊 Needle-Free (Oral)
HILLCHOL® · Bharat Biotech · 5 × 1.5 mL Single-Dose Respules · Oral Use Only – Do Not Inject
Composition per 1.5 mL dose: Formaldehyde-inactivated V. cholerae O1 El Tor Hikojima whole cell (≥900 µg LPS) in phosphate buffered saline
👥 Who Should Get HILLCHOL?
Cholera spreads through contaminated water and food, and can cause severe dehydration within hours. HILLCHOL is recommended for:
- Travelers heading to cholera-endemic countries or regions with active outbreaks in Africa, South Asia and parts of Latin America.
- Individuals living in or moving into flood-affected, low-sanitation or refugee/relief-camp settings where clean water access is uncertain.
- Food handlers, healthcare and sanitation workers, and disaster-relief personnel working in high-risk environments.
- Household members and close contacts during a confirmed local cholera outbreak, as advised by public health authorities.
- Individuals aged 1 year and above seeking a needle-free, single-dose option for cholera prevention ahead of travel or seasonal outbreak risk (monsoon/flood season).
🔬 HILLCHOL Composition – Per 1.5 mL Oral Dose
Each single-dose respule contains:
| Component | Quantity | Notes |
|---|---|---|
| ACTIVE INGREDIENT | ||
| Formaldehyde-inactivated whole-cell Vibrio cholerae O1 El Tor Hikojima serotype (recombinant strain) Killed whole-cell antigen – not a live vaccine |
≥900 µg of LPS | Lipopolysaccharide (LPS) content per dose, as declared on the pack insert |
| PRESENTATION & EXCIPIENTS | ||
| Phosphate buffered saline | q.s. to 1.5 mL | Oral suspension vehicle; no adjuvant or preservative injection required |
| Formulation | Ready-to-use oral suspension | Supplied in single-dose, twist-off respules – 5 per strip |
Composition as declared on the HILLCHOL pack insert (Bharat Biotech, Mfg. Lic. No. 03/HD/AP/98/V/R). Store at +2°C to +8°C; do not freeze; discard if frozen.
📅 HILLCHOL Vaccination Schedule
| Regimen / Group | Number of Doses | Timing | Notes |
|---|---|---|---|
| STANDARD PROTECTION | |||
| Primary Dose (Oral) | 1 Dose | Single 1.5 mL oral dose, ideally at least 1–2 weeks before travel or anticipated exposure | No injection; respule contents poured directly into the mouth under supervision |
| CONTINUED / REPEATED RISK | |||
| Booster Dose | As advised | Per physician's advice for individuals with ongoing or repeated cholera exposure risk | Duration of protection after a single dose is being studied; follow your doctor's guidance for repeat travel/outbreak exposure |
Schedule reflects HILLCHOL's single-dose design. Always confirm timing with your physician, especially close to travel dates or during an active local outbreak.
⚙️ How Does HILLCHOL Work?
1
Oral Antigen Delivery
The 1.5 mL respule is poured directly into the recipient's mouth and swallowed – no needle, injection or cold-chain syringe is involved. The inactivated whole-cell antigen travels to the gut.
2
Mucosal Immune Recognition
Gut-associated lymphoid tissue (GALT) encounters the killed V. cholerae O1 antigens and lipopolysaccharide (LPS), activating local immune cells without any risk of causing cholera, since the bacteria are fully inactivated.
3
Antibody & Memory Cell Formation
The immune system produces intestinal IgA and systemic antibodies directed against V. cholerae O1 surface antigens, along with immune memory cells for faster response on future exposure.
4
Protection at the Gut Lining
On future exposure to toxigenic V. cholerae O1 through contaminated food or water, primed antibodies help block bacterial attachment and toxin activity at the intestinal lining, reducing the risk of severe watery diarrhoea.
⚠️ HILLCHOL Side Effects
Because HILLCHOL is swallowed rather than injected, there is no injection-site reaction. Most recipients tolerate it well, with only mild, short-lived reactions if any.
🟡 Common (Mild, 1–2 Days)
- 🤢 Mild nausea or abdominal discomfort
- 💩 Loose stools
- 🤕 Mild headache
- 🌡️ Low-grade fever
- 🍽️ Temporary reduced appetite
🔴 Rare – Seek Medical Attention
- 😮💨 Difficulty breathing or facial/throat swelling (anaphylaxis)
- 🌡️ High fever (above 39.5°C / 103°F)
- 🟣 Widespread rash or hives
- 💧 Persistent vomiting or watery diarrhoea after dosing
- 😵 Fainting or severe dizziness shortly after dosing
⚖️ HILLCHOL vs Other Oral Cholera Vaccines
| Feature | HILLCHOL (Bharat Biotech) | Euvichol-Plus | Shanchol / Dukoral |
|---|---|---|---|
| Number of Doses | ✓ Single dose | 2 doses, 14 days apart | 2 doses, 14 days apart |
| Route | Oral | Oral | Oral |
| Vaccine Type | Inactivated whole-cell (O1) | Inactivated whole-cell (O1 + O139) | Inactivated whole-cell (± B subunit for Dukoral) |
| Country of Manufacture | ✓ Made in India | Imported (South Korea) | Imported |
| Time to Complete Protection | ✓ Immediate after 1 visit | 2 visits, 2 weeks apart | 2 visits, 2 weeks apart |
| Convenience for Last-Minute Travel | ✓ Ideal – single visit | Needs planning ahead | Needs planning ahead |
Comparison is for general informational purposes based on publicly available regimen information; VacciHub currently offers HILLCHOL. Consult your doctor for vaccine selection based on your travel destination and health profile.
🚫 Precautions and Contraindications
Use with Caution – Consult Doctor First:
- Known severe allergic reaction to a previous dose of HILLCHOL or any of its components.
- Acute moderate-to-severe gastrointestinal illness or fever – defer dosing until recovery.
- Pregnant or breastfeeding women should consult their doctor before taking HILLCHOL.
- Immunocompromised individuals should discuss suitability with their physician, though HILLCHOL contains no live bacteria.
- Infants below 1 year of age – HILLCHOL is not indicated below this age.
Important Reminder:
- HILLCHOL does not replace safe drinking water, food hygiene, sanitation and handwashing – these remain essential to prevent cholera and other waterborne illnesses.
🏥 Why Book HILLCHOL with VacciHub
Certified Nursing Staff
Nurses trained in oral vaccine administration and pre-dose assessment, ensuring the single dose is given correctly on every home visit.
Proper Cold Chain Handling
HILLCHOL respules are transported and stored at 2–8°C as required, never frozen, right up to your doorstep.
Genuine Bharat Biotech HILLCHOL
Sourced exclusively from authorised distributors. Batch number and expiry shared on your WhatsApp receipt post-vaccination.
Pre & Post-Dose Guidance
Our nurses explain what to expect after the oral dose and when a booster may be relevant for repeated travel or exposure.
📍 HILLCHOL Home Vaccination – Cities We Serve
🏛️Delhi (All Areas)
🏙️Gurgaon
🌆Noida
🏘️Ghaziabad
🏗️Faridabad
🌇Greater Noida
Call +91 92050 04114 to confirm service availability for your pincode – book a few days ahead of travel where possible.
❓ Frequently Asked Questions – HILLCHOL
HILLCHOL is a Cholera Vaccine (Inactivated, Oral) manufactured by Bharat Biotech. It is India's single-dose oral cholera vaccine, given as an oral suspension rather than an injection.
HILLCHOL is given orally as a single 1.5 mL dose. The respule is twisted and detached from the strip and the liquid is poured directly into the recipient's mouth – no injection or needle is involved.
HILLCHOL is designed as a single-dose regimen, unlike older two-dose oral cholera vaccines such as Shanchol or Euvichol-Plus. Your doctor may advise a booster dose if you remain at continued risk of exposure.
HILLCHOL is recommended for travelers to cholera-endemic or outbreak-affected areas, people living in flood-prone or low-sanitation areas, food handlers, and individuals aged 1 year and above at elevated risk of cholera exposure.
Most recipients experience no side effects. When they occur, they are typically mild and short-lived – such as mild abdominal discomfort, nausea, loose stools or a mild headache.
HILLCHOL is indicated for individuals aged 1 year and above. Please consult your doctor to confirm suitability for your child's age and health status.
No. HILLCHOL is an additional layer of protection and does not replace safe drinking water, food hygiene, sanitation, and handwashing precautions, which remain essential for preventing cholera.
Yes. VacciHub's certified nurses can administer the single oral dose of HILLCHOL at home across Delhi, Gurgaon, Noida, Ghaziabad and Faridabad, with proper cold-chain handling and post-dose guidance.